Journal article
Longitudinal visual field archetypal analysis of optic neuritis treated in a clinical setting
BMJ open ophthalmology, Vol.7(1), p.e001136
11/16/2022
DOI: 10.1136/bmjophth-2022-001136
PMCID: PMC9670935
Abstract
Background/aimsWe previously used archetypal analysis (AA) to create a model that quantified patterns (archetypes (ATs)) of visual field (VF) loss that can predict recovery and reveal residual VF deficits from eyes in the Optic Neuritis Treatment Trial (ONTT). We hypothesised that AA could produce similar results for ON VFs collected in clinical practice.MethodsWe applied AA to a retrospective data set of 486 VFs collected in 1 neuro-ophthalmology service from 141 eyes with acute ON and typical VF defects, to create a clinic-derived AT model. We also used the ONTT-derived AT model to analyse this new dataset. We compared the findings of both models by decomposing VFs into component ATs of varying per cent weight (PW), correlating presentation AT PW with mean deviation (MD) at final visits for each eye and identifying residual deficits in VFs considered normal.ResultsBoth models, each with 16 ATs, decomposed each presentation VF into 0–6 abnormal ATs representative of known patterns of ON-related VF loss. AT1, the normal pattern in both models, correlated strongly with MD for VFs collected at presentation (r=0.82; p<0.001) and the final visit (r=0.81, p<0.001). The presentation AT1 PW was associated with improvement in MD over time. 67% of VFs considered ‘normal’ at final visit had 1.2±0.4 abnormal ATs, and both models revealed similar patterns of regional VF loss.ConclusionsAA is a quantitative method to measure change and outcome of ON VFs. Presentation AT features are associated with MD at final visit. AA identifies residual VF deficits not otherwise indicated by MD.
Details
- Title: Subtitle
- Longitudinal visual field archetypal analysis of optic neuritis treated in a clinical setting
- Creators
- Joseph Branco - New York Medical CollegeTobias Elze - Massachusetts Eye and Ear InfirmaryJui-Kai Wang - University of IowaLouis R Pasquale - Icahn School of Medicine at Mount SinaiMona K Garvin - University of IowaRandy Kardon - University of IowaMark J Kupersmith - Neurology/Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Resource Type
- Journal article
- Publication Details
- BMJ open ophthalmology, Vol.7(1), p.e001136
- DOI
- 10.1136/bmjophth-2022-001136
- PMCID
- PMC9670935
- ISSN
- 2397-3269
- eISSN
- 2397-3269
- Publisher
- BMJ Publishing Group Ltd
- Grant note
- EY015473; EY032522 / National Eye Institute (http://dx.doi.org/10.13039/100000053) Alfiero & Lucia Palestroni Foundation, Inc Research to Prevent Blindness, Inc New York Eye and Ear Infirmary Foundation
- Language
- English
- Date published
- 11/16/2022
- Academic Unit
- Electrical and Computer Engineering; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9984317459302771
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