Journal article
Long‐term outcomes up to 25 years following balloon pulmonary valvuloplasty: A multicenter study
Congenital heart disease, Vol.14(6), pp.1037-1045
11/2019
DOI: 10.1111/chd.12788
PMID: 31250555
Abstract
Objective: Evaluate long-term outcomes following balloon pulmonary valvuloplasty (BPV) for pulmonary stenosis (PS).
Background: Long-term data following BPV is limited to small, single center studies.
Methods: BPV from April 12, 1985 to January 7, 2015 from three centers were included. Outcomes studied were ≥ moderate PI by echocardiogram and residual PS ≥ 40 mm Hg. Risk factors for ≥ moderate PI, residual PS, and repeat intervention were assessed by univariate and multivariate analysis.
Results: Among 254 patients, mean age at BPV was 3.8 years (range 1 day-67 years), initial PS catheter gradient was 56 mm Hg (IQR 40-70), 19% had critical PS, and 9% had genetic syndromes. Mean follow-up duration was 7.5 years (maximum 25 years). Sixty-nine (29%) had ≥ moderate PI, 41 patients (17%) had residual PS > 40 mm Hg, and 31 (13%) had re-intervention. In univariate analysis, younger age, lower weight, greater initial PS gradient, greater initial RV/systemic pressure ratio, critical PS, and longer follow-up duration were associated with ≥ moderate PI. Greater initial PS gradient was associated with long-term residual PS or repeat intervention. In multivariate analysis, greater initial gradient and lower weight were independently associated with > moderate PI and greater initial PS gradient and genetic abnormality were independently associated with residual PS and repeat intervention.
Conclusion: Smaller patients with greater initial PS were more likely to develop significant long-term PI. Patients with greater initial PS and genetic abnormalities were more likely to have residual PS or require repeat intervention following BPV.
Details
- Title: Subtitle
- Long‐term outcomes up to 25 years following balloon pulmonary valvuloplasty: A multicenter study
- Creators
- Rachel L. Hansen - University of Rochester Medical CenterIman Naimi - SUNY Upstate Medical UniversityHongyue Wang - University of Rochester Medical CenterNader Atallah - SUNY Upstate Medical UniversityFrank Smith - SUNY Upstate Medical UniversityCraig Byrum - SUNY Upstate Medical UniversityDaniel Kveselis - SUNY Upstate Medical UniversityGlenn Leonard - University of Rochester Medical CenterRajiv Devanagondi - University of Rochester Medical CenterMatthew Egan - Hematology Oncology Associates of Central New York
- Resource Type
- Journal article
- Publication Details
- Congenital heart disease, Vol.14(6), pp.1037-1045
- DOI
- 10.1111/chd.12788
- PMID
- 31250555
- ISSN
- 1747-079X
- eISSN
- 1747-0803
- Number of pages
- 9
- Language
- English
- Date published
- 11/2019
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984772258602771
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