Long‐term plasticity of corticostriatal synapses is modulated by pathway‐specific co‐release of opioids through κ‐opioid receptors

Sarah L. Hawes; Armando G. Salinas; David M. Lovinger; Kim T. Blackwell

doi:10.1113/JP274190

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Long‐term plasticity of corticostriatal synapses is modulated by pathway‐specific co‐release of opioids through κ‐opioid receptors

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Long‐term plasticity of corticostriatal synapses is modulated by pathway‐specific co‐release of opioids through κ‐opioid receptors

Sarah L. Hawes, Armando G. Salinas, David M. Lovinger and Kim T. Blackwell

The Journal of physiology, Vol.595(16), pp.5637-5652

08/15/2017

DOI: 10.1113/JP274190

PMCID: PMC5556153

PMID: 28449351

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Abstract

Both endogenous opioids and opiate drugs of abuse modulate learning of habitual and goal‐directed actions, and can also modify long‐term plasticity of corticostriatal synapses. Striatal projection neurons of the direct pathway co‐release the opioid neuropeptide dynorphin which can inhibit dopamine release via κ‐opioid receptors. Theta‐burst stimulation of corticostriatal fibres produces long‐term potentiation (LTP) in striatal projection neurons when measured using whole‐cell patch recording. Optogenetic activation of direct pathway striatal projection neurons inhibits LTP while reducing dopamine release. Because the endogenous release of opioids is activity dependent, this modulation of synaptic plasticity represents a negative feedback mechanism that may limit runaway enhancement of striatal neuron activity in response to drugs of abuse.

dopamine

dynorphin

electrophysiology

Molecular

Neuroscience ‐ Cellular

Research Paper

striatum

synaptic plasticity

voltammetry

Details

Title: Subtitle: Long‐term plasticity of corticostriatal synapses is modulated by pathway‐specific co‐release of opioids through κ‐opioid receptors
Creators: Sarah L. Hawes - George Mason University
Armando G. Salinas - National Institute on Alcohol Abuse and Alcoholism
David M. Lovinger - National Institute on Alcohol Abuse and Alcoholism
Kim T. Blackwell - George Mason University
Resource Type: Journal article
Publication Details: The Journal of physiology, Vol.595(16), pp.5637-5652
DOI: 10.1113/JP274190
PMID: 28449351
PMCID: PMC5556153
NLM abbreviation: J Physiol
ISSN: 0022-3751
eISSN: 1469-7793
Publisher: John Wiley and Sons Inc
Grant note: Division of Intramural Clinical and Biological Research MURI N00014‐10‐1‐0198 / Office of Naval Research R01AA16022 / NIAAA
Alternative title: S. L. Hawes and others
Language: English
Date published: 08/15/2017
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
Record Identifier: 9984446410802771

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