Journal article
Losartan for Preventing Aortic Root Dilatation in Patients with Marfan Syndrome: A Meta-Analysis of Randomized Trials
Cardiology and therapy, Vol.8(2), pp.365-372
12/01/2019
DOI: 10.1007/s40119-019-00149-3
PMCID: PMC6828927
PMID: 31606871
Abstract
Introduction The role of losartan in preventing aortic root dilatation in Marfan syndrome has been evaluated in many clinical trials; however, the results are conflicting. Methods We performed a computerized search of MEDLINE, EMBASE and COCHRANE databases through February 2019 for randomized clinical trials evaluating the effect of losartan in patients with Marfan syndrome. The main outcome was the change in the aortic root diameter in the losartan versus control groups. Results Our final analysis included seven randomized trials with a total of 1352 patients and average weighted follow-up of 37.8 months. Change in aortic root diameter was significantly smaller with losartan compared with control [weighted means: 0.44 vs. 0.58 mm, mean difference (MD) = -0.13; 95% CI -0.24 to -0.02; p = 0.02]. Subgroup analysis according to the control group showed no significant subgroup interaction when comparing losartan with beta-blockers versus with standard therapy (p(interaction=) 0.27). The composite outcome of aortic surgery, dissection or mortality did not differ between the losartan and control groups (risk ratio = 1.03; 95% CI 0.72-1.49, p = 0.86). Conclusion In this meta-analysis including seven randomized trials, the use of losartan was associated with a significantly smaller change in aortic root diameter in patients with Marfan syndrome.
Details
- Title: Subtitle
- Losartan for Preventing Aortic Root Dilatation in Patients with Marfan Syndrome: A Meta-Analysis of Randomized Trials
- Creators
- Ayman Elbadawi - The University of Texas Medical Branch at GalvestonMohamed A. Omer - Minneapolis Heart Institute FoundationIslam Y. Elgendy - Massachusetts General HospitalAhmed Abuzaid - University of California, San FranciscoAhmed H. Mohamed - Rochester General Health SystemDevesh Rai - Rochester General Health SystemMarwan Saad - Brown UniversityAmgad Mentias - University of IowaAhmed Rezq - Ain Shams UniversityDiaa Kamal - Ain Shams UniversityWissam Khalife - The University of Texas Medical Branch at GalvestonBarry London - University of IowaMohamed Morsy - University of Virginia
- Resource Type
- Journal article
- Publication Details
- Cardiology and therapy, Vol.8(2), pp.365-372
- DOI
- 10.1007/s40119-019-00149-3
- PMID
- 31606871
- PMCID
- PMC6828927
- NLM abbreviation
- Cardiol Ther
- ISSN
- 2193-8261
- eISSN
- 2193-6544
- Publisher
- Springer Nature
- Number of pages
- 8
- Language
- English
- Date published
- 12/01/2019
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984297599602771
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