Journal article
Losartan/hydrochlorothiazide combination is safe and effective for morning hypertension in Very-Elderly patients
Clinical and experimental hypertension (1993), Vol.40(3), pp.267-273
01/01/2018
DOI: 10.1080/10641963.2017.1368536
PMID: 29083936
Abstract
Morning hypertension is an independent risk for cerebrovascular and cardiovascular events. Although the prevalence of morning hypertension increases with age, treatment of morning hypertension has not been established, particularly in Very-Elderly patients. We compared the safety and efficacy of a losartan/hydrochlorothiazide (HCTZ) combination in controlling morning hypertension between Very-Elderly (≥75 years) and Young/Elderly patients (<75 years). This study was a subanalysis of the Morning Hypertension and Angiotensin Receptor Blocker/Hydrochlorothiazide Combination Therapy study, in which patients with morning hypertension (≥135/85 mmHg) received a 50-mg losartan/12.5-mg HCTZ combination tablet (combination therapy) or 100-mg losartan (high-dose therapy) for 3 months. High adherence rates and few adverse effects were observed in Very-Elderly patients receiving combination (n = 32) and high-dose (n = 34) therapies and in Young/Elderly patients receiving combination (n = 69) and high-dose (n = 66) therapies. Baseline morning systolic BP (SBP) was similar in both age groups receiving either therapy. Morning SBP was reduced by 20.2 and 18.1 mmHg with combination therapy and by 7.1 and 9.1 mmHg with high-dose therapy in the Very-Elderly and Young/Elderly patients, respectively. Morning BP target (<135/85 mmHg) was achieved in 40.6% and 55.1% by combination therapy and in 14.7% and 24.2% by high-dose therapy in the Very-Elderly and Young/Elderly patients, respectively. Neither therapy changed renal function and serum potassium in Very-Elderly patients. In conclusion, the losartan/HCTZ combination was safe and effective in controlling morning hypertension in Very-Elderly as well as Young/Elderly patients. In addition, combination therapy was also superior to high-dose therapy for lowering morning SBP in Very-Elderly patients.
Details
- Title: Subtitle
- Losartan/hydrochlorothiazide combination is safe and effective for morning hypertension in Very-Elderly patients
- Creators
- Hiroki Uchiwa - Kurume UniversityHisashi Kai - Kurume University Medical CenterYoshiko Iwamoto - Kurume UniversityTakahiro Anegawa - Kurume UniversityHidemi Kajimoto - University of WashingtonKenji Fukuda - Kurume UniversityTsutomu Imaizumi - Fukuoka International UniversityYoshihiro Fukumoto - Kurume UniversityMAPPY Study Investigators
- Resource Type
- Journal article
- Publication Details
- Clinical and experimental hypertension (1993), Vol.40(3), pp.267-273
- DOI
- 10.1080/10641963.2017.1368536
- PMID
- 29083936
- NLM abbreviation
- Clin Exp Hypertens
- ISSN
- 1064-1963
- eISSN
- 1525-6006
- Publisher
- Taylor & Francis
- Number of pages
- 7
- Grant note
- 16K09468; 16K09468 / MEXT/JSPS KAKENHI N/A / Un-restricted research funding from MSD, Japan 2015-01 / Kurume University Millennium Box Foundation for the Promotion of Science
- Language
- English
- Date published
- 01/01/2018
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984961114102771
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