Journal article
Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in COPD
American journal of respiratory and critical care medicine, Vol.210(2), pp.186-200
01/23/2024
DOI: 10.1164/rccm.202303-0489OC
PMCID: PMC11273318
PMID: 38261629
Abstract
Rationale: The airway microbiome has the potential to shape COPD pathogenesis, but its relationship to outcomes in milder disease is unestablished.
Objectives: Identify sputum microbiome characteristics associated with markers of COPD in participants of the SubPopulations and InteRmediate Outcome Measures of COPD Study (SPIROMICS).
Methods: Sputum DNA from 877 participants were analyzed using 16S rRNA gene sequencing. Relationships between baseline airway microbiota composition and clinical, radiographic and muco-inflammatory markers, including longitudinal lung function trajectory, were examined.
Measurements and main results: Participant data represented predominantly milder disease (GOLD 0-2: N=732/877). Phylogenetic diversity (range of different species within a sample) correlated positively with baseline lung function, declined with higher GOLD stage, and correlated negatively with symptom burden, radiographic markers of airway disease, and total mucin concentrations (p<0.001). In co-variate adjusted regression models, organisms robustly associated with better lung function included members of Alloprevotella, Oribacterium, and Veillonella. Conversely, lower lung function, greater symptoms and radiographic measures of small airway disease associated with enrichment in members of Streptococcus, Actinobacillus, Actinomyces, and other genera. Baseline sputum microbiota features also associated with lung function trajectory during SPIROMICS follow up (stable/improved, decliner, or rapid decliner). The 'stable/improved' group (slope of FEV1 regression ≥ 66th percentile) had higher bacterial diversity at baseline, associated with enrichment in Prevotella, Leptotrichia, and Neisseria. In contrast, the 'rapid decliner' group (FEV1 slope ≤ 33rd percentile) had significantly lower baseline diversity, associated with enrichment in Streptococcus.
Conclusions: In SPIROMICS baseline airway microbiota features demonstrate divergent associations with better or worse COPD-related outcomes.
Details
- Title: Subtitle
- Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in COPD
- Creators
- Kristopher Opron - University of MichiganLesa A. Begley - University of MichiganJohn R Erb-Downward - University of MichiganGen Li - University of MichiganNeil E. Alexis - University of North Carolina at Chapel HillIgor Barjaktarevic - University of California, Los AngelesR Graham Barr - Columbia UniversityEugene R. Bleecker - University of ArizonaRichard Boucher - University of North Carolina at Chapel HillRussell P. Bowler - National Jewish HealthStephanie A Christenson - University of California, San FranciscoAlejandro P. Comellas - University of IowaGerard Criner - Temple University HospitalChristopher B. Cooper - Harbor–UCLA Medical CenterDavid Couper - University of North Carolina at Chapel HillCraig J Galban - University of MichiganMeiLan K. Han - University of MichiganAnnette Hastie - Wake Forest UniversityCharles Hatt - Imbio (United States)Eric A. Hoffman - University of IowaRobert J Kaner - Cornell UniversityMehmet Kesimer - University of North Carolina at Chapel HillJerry A Krishnan - University of Illinois ChicagoDavid C. LaFon - University of Alabama at BirminghamFernando J. Martinez - Cornell UniversityVictor E. Ortega - Mayo Clinic in ArizonaStephen P. Peters - Wake Forest UniversityRobert Paine III - University of UtahNirupama Putcha - Johns Hopkins UniversityPrescott G. Woodruff - University of California, San FranciscoGary B Huffnagle - University of MichiganAriangela J. Kozik - University of MichiganJeffrey L. Curtis - Michigan MedicineYvonne J Huang - University of MichiganSPIROMICS Investigators
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.210(2), pp.186-200
- DOI
- 10.1164/rccm.202303-0489OC
- PMID
- 38261629
- PMCID
- PMC11273318
- NLM abbreviation
- Am J Respir Crit Care Med
- ISSN
- 1073-449X
- eISSN
- 1535-4970
- Publisher
- American Thoracic Society
- Language
- English
- Electronic publication date
- 01/23/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
- Record Identifier
- 9984548479302771
Metrics
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