Journal article
Loss of Leptin Actions in Obesity: Two Concepts with Cardiovascular Implications
Clinical and experimental hypertension (1993), Vol.26(7-8), pp.629-636
2004
DOI: 10.1081/CEH-200031948
PMID: 15702617
Abstract
Obesity is associated with increased risk of hypertension and heart disease. Leptin has recently been linked to increased risk of cardiovascular disease. We review briefly here two concepts regarding loss of leptin actions that have potential implications for cardiovascular disease. These are: 1. the concept of selective leptin resistance; and 2. the concept that loss of leptin action results in lipid accumulation and lipotoxicity of skeletal muscle, pancreatic islet cells, and heart and, thereby, promotes insulin resistance, insulin deficiency and cardiac dysfunction, respectively.
Details
- Title: Subtitle
- Loss of Leptin Actions in Obesity: Two Concepts with Cardiovascular Implications
- Creators
- Allyn L Mark - 1Hypertension Genetics Specialized Center of Research, Cardiovascular Center, University of Iowa, Iowa City, IowaUSAMarcelo L. G Correia - 1Hypertension Genetics Specialized Center of Research, Cardiovascular Center, University of Iowa, Iowa City, IowaUSAKamal Rahmouni - 1Hypertension Genetics Specialized Center of Research, Cardiovascular Center, University of Iowa, Iowa City, IowaUSAWilliam G Haynes - 1Hypertension Genetics Specialized Center of Research, Cardiovascular Center, University of Iowa, Iowa City, IowaUSA
- Resource Type
- Journal article
- Publication Details
- Clinical and experimental hypertension (1993), Vol.26(7-8), pp.629-636
- Publisher
- Informa UK Ltd
- DOI
- 10.1081/CEH-200031948
- PMID
- 15702617
- ISSN
- 1064-1963
- eISSN
- 1525-6006
- Language
- English
- Date published
- 2004
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984040325602771
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