Loss of Peak Vision in Retinal Vein Occlusion Patients Treated for Macular Edema

Mustafa Iftikhar; Tahreem A Mir; Gulnar Hafiz; Ingrid Zimmer-Galler; Adrienne W Scott; Sharon D Solomon; Akrit Sodhi; Adam S Wenick; Catherine Meyerle; Kim Jiramongkolchai; T Y Alvin Liu; J Fernando Arevalo; Mandeep Singh; Saleema Kherani; James T Handa; Peter A Campochiaro

doi:10.1016/j.ajo.2019.03.029

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Loss of Peak Vision in Retinal Vein Occlusion Patients Treated for Macular Edema

Journal article

Peer reviewed

Loss of Peak Vision in Retinal Vein Occlusion Patients Treated for Macular Edema

Mustafa Iftikhar, Tahreem A Mir, Gulnar Hafiz, Ingrid Zimmer-Galler, Adrienne W Scott, Sharon D Solomon, Akrit Sodhi, Adam S Wenick, Catherine Meyerle, Kim Jiramongkolchai, …

American journal of ophthalmology, Vol.205, pp.17-26

09/01/2019

DOI: 10.1016/j.ajo.2019.03.029

PMCID: PMC10019499

PMID: 30954469

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10019499/pdf/nihms-1878070.pdfView

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Abstract

To evaluate long-term visual and anatomic outcomes in patients with retinal vein occlusion (RVO) treated with anti-vascular endothelial growth factor (VEGF) agents. Prospective, interventional case series. Patients with central RVO (CRVO) or branch RVO (BRVO). Number of anti-VEGF injections and improvement from baseline best-corrected visual acuity (BCVA) and central subfield thickness (CST) were prospectively recorded in 40 eyes of 39 CRVO patients and 50 eyes of 47 BRVO patients. Mean follow-up was 58 months for BRVO and 78 months for CRVO. Within 6 months of last follow-up, 58% of BRVO patients and 75% of CRVO patients required anti-VEGF injections to control edema. Analysis of the course of each patient over time showed that for BRVO patients, BCVA letter score increased by a mean of 24, from baseline of 52 (20/100) to peak of 76 (20/32), and subsequently decreased by 13, to 63 (20/50), at final visit; and for CRVO patients, BCVA letter score increased by a mean of 26, from baseline of 48 (20/100) to peak of 74 (20/32), and subsequently decreased by 18, to 56 (20/80), at last follow-up. Loss from peak BCVA occurred primarily owing to persistent/recurrent edema and related foveal damage. Patients with RVO showed large improvements in BCVA after initiation of anti-VEGF injections, but in many patients some visual gains were lost over time owing to bouts of recurrent edema. Sustained suppression of VEGF may help to provide optimal outcomes in RVO and reduce treatment burden.

Angiogenesis Inhibitors - administration & dosage

Disease Progression

Follow-Up Studies

Intravitreal Injections

Macular Edema - drug therapy

Macular Edema - etiology

Macular Edema - physiopathology

Pilot Projects

Prospective Studies

Ranibizumab - administration & dosage

Retinal Vein Occlusion - complications

Retinal Vein Occlusion - physiopathology

Time Factors

Vascular Endothelial Growth Factor A - antagonists & inhibitors

Visual Acuity

Details

Title: Subtitle: Loss of Peak Vision in Retinal Vein Occlusion Patients Treated for Macular Edema
Creators: Mustafa Iftikhar - Johns Hopkins University
Tahreem A Mir - Johns Hopkins University
Gulnar Hafiz - Johns Hopkins University
Ingrid Zimmer-Galler - Johns Hopkins University
Adrienne W Scott - Johns Hopkins University
Sharon D Solomon - Johns Hopkins University
Akrit Sodhi - Johns Hopkins University
Adam S Wenick - Johns Hopkins University
Catherine Meyerle - Johns Hopkins University
Kim Jiramongkolchai - Johns Hopkins University
T Y Alvin Liu - Johns Hopkins University
J Fernando Arevalo - Johns Hopkins University
Mandeep Singh - Johns Hopkins University
Saleema Kherani - Johns Hopkins University
James T Handa - Johns Hopkins University
Peter A Campochiaro - Johns Hopkins University
Resource Type: Journal article
Publication Details: American journal of ophthalmology, Vol.205, pp.17-26
DOI: 10.1016/j.ajo.2019.03.029
PMID: 30954469
PMCID: PMC10019499
NLM abbreviation: Am J Ophthalmol
ISSN: 0002-9394
eISSN: 1879-1891
Grant note: R01 EY029750 / NEI NIH HHS R01 EY025705 / NEI NIH HHS
Language: English
Date published: 09/01/2019
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9984756258402771

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