Journal article
Loss of genes in chromosome arms 5q and 16q in breast cancer
Breast disease, Vol.41(1), pp.331-341
08/10/2022
DOI: 10.3233/BD-210047
PMID: 35964165
Abstract
INTRODUCTION: Losses of genetic material from chromosomes 5q and 16q commonly occur in sub-sets of breast cancer. Their significance from a pathophysiologic point of view is not well-defined. METHODS: This study uses publicly available genomic data from extensive breast cancer datasets to define the landscape of losses in chromosomal arms 5q and 16q in the two sub-types of breast cancer they most commonly occur, basal-like and luminal A cancers, respectively. RESULTS: It is shown that dozens of genes from these chromosomal arms are putatively hemi-deleted in few samples each. No individual gene from either 5q or 16q shows an incidence of deep deletion above 10% in the cohorts with basal-like and luminal A cancers or in the whole cohorts. A few tumor suppressor genes are deleted in a small number of samples, less than 5% in each cohort. Losses of 5q or 16q confer no survival advantage in either the basal-like or the luminal A cohorts from TCGA that harbor them. CONCLUSION: Results suggest that there are no individual genes in chromosomes 5q and 16q whose loss can be implicated in a dominant pathophysiologic sequence of events in breast cancer or its sub-sets.
Details
- Title: Subtitle
- Loss of genes in chromosome arms 5q and 16q in breast cancer
- Creators
- Ioannis A. Voutsadakis - NOSM University
- Resource Type
- Journal article
- Publication Details
- Breast disease, Vol.41(1), pp.331-341
- DOI
- 10.3233/BD-210047
- PMID
- 35964165
- NLM abbreviation
- Breast Dis
- ISSN
- 0888-6008
- eISSN
- 1558-1551
- Number of pages
- 11
- Language
- English
- Date published
- 08/10/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806503002771
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