Journal article
Loss of trabecular meshwork stem cells is correlated with open angle glaucoma
Experimental eye research, Vol.253, 110296
02/14/2025
DOI: 10.1016/j.exer.2025.110296
PMID: 39956352
Abstract
The trabecular meshwork (TM) of the eye is critical in maintaining aqueous humor outflow and intraocular pressure (IOP). The cellular density in the TM decreases with age and is particularly low in eyes with glaucoma. TM cells are thought to be derived from a population of stem cells, referred to as TM stem cells (TMSCs). To investigate the relationship between TM cellular density and TMSCs, the number of TMSCs and TM cells was compared in human eyes obtained from young donors, individuals with glaucoma, and age-matched controls. Findings obtained confirm that eyes of younger donors contain the largest number of TM cells, while those of older healthy donors contained more TM cells than glaucomatous eyes of the same age (p = 0.0007). Likewise, we detected the largest number of TMSCs in young eyes, significantly higher than in healthy older eyes (p < 0.0001). Again, eyes from glaucomatous patients contained fewer TMSC than those of healthy donors (p < 0.0001). Together the data indicate a clear decline in the number of TMSCs with age and a further reduction in eyes with glaucoma. Although this study does not establish causality, our finding is consistent with the notion that the degeneration or loss of stemness of TMSCs is the cause of reduced TM cellularity which, in turn, is associated with TM dysfunction and the development of elevated IOP.
Details
- Title: Subtitle
- Loss of trabecular meshwork stem cells is correlated with open angle glaucoma
- Creators
- Sarah Brumley - University of IowaShuyu Xian - University of Iowa, Ophthalmology and Visual SciencesMarkus H Kuehn - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Experimental eye research, Vol.253, 110296
- Publisher
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
- DOI
- 10.1016/j.exer.2025.110296
- PMID
- 39956352
- ISSN
- 0014-4835
- eISSN
- 1096-0007
- Grant note
- United States ( U.S.) Department of Veterans Affairs Rehabilitation Research and Development Service: 1 I01 RX002860, 1I50RX003002-01 Research to Prevent Blindness
This work was supported by Merit Review Award 1 I01 RX002860 and Center Grant 1I50RX003002-01 from the United States ( U.S.) Department of Veterans Affairs Rehabilitation Research and Development Service as well as an unrestricted grant to the University of Iowa Department of Ophthalmology from Research to Prevent Blindness.
- Language
- English
- Date published
- 02/14/2025
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984790998302771
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