Journal article
Low Birth Weight and Risk of Later-Life Physical Disability in Women
The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.72(4), pp.543-547
04/01/2017
DOI: 10.1093/gerona/glw134
PMCID: PMC6075587
PMID: 27440911
Abstract
There is strong evidence that low and high birth weight due to in-utero programming results in elevated risk for adult diseases, though less research has been performed examining the influence of birth weight and physical disability later in life.
Baseline data from 76,055 postmenopausal women in the Women's Health Initiative, a large multi-ethnic cohort, were used to examine the association between self-reported birth weight category (<6 lbs, 6-7 lbs 15 oz, 8-9 lbs 15 oz, and ≥10 lbs) and the self-reported physical functioning score on the RAND 36-item Health Survey. Linear regression models were adjusted for age, education, race/ethnicity, body mass index, and a comorbidity score.
Unadjusted models indicate that women born in the lowest and highest birth weight categories have significantly lower physical functioning scores as compared to women born in the normal weight category (β = -2.22, p < .0001 and β = -3.56, p < .0001, respectively). After adjustments, the relationship between the lowest birth weight category and physical functioning score remained significant (β = -1.52, p < .0001); however, the association with the highest birth weight category dissipated.
Preconception and prenatal interventions aimed at reducing the incidence of low birth weight infants may subsequently reduce the burden of later-life physical disability.
Details
- Title: Subtitle
- Low Birth Weight and Risk of Later-Life Physical Disability in Women
- Creators
- Cassandra N Spracklen - Department of Genetics, University of North Carolina-Chapel HillKelli K Ryckman - Department of Epidemiology, University of Iowa College of Public Health, Iowa CityJennifer G Robinson - Department of Epidemiology, University of Iowa College of Public Health, Iowa CityMarcia L Stefanick - Department of Medicine, Stanford University, CaliforniaGloria E Sarto - Department of Obstetrics and Gynecology, University of Wisconsin, MadisonStephen D Anton - Department of Aging and Geriatric Medicine, University of Florida, GainsvilleRobert B Wallace - Department of Epidemiology, University of Iowa College of Public Health, Iowa City
- Resource Type
- Journal article
- Publication Details
- The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.72(4), pp.543-547
- DOI
- 10.1093/gerona/glw134
- PMID
- 27440911
- PMCID
- PMC6075587
- NLM abbreviation
- J Gerontol A Biol Sci Med Sci
- ISSN
- 1079-5006
- eISSN
- 1758-535X
- Publisher
- United States
- Grant note
- P30 AG028740 / NIA NIH HHS M01 RR000059 / NCRR NIH HHS
- Language
- English
- Date published
- 04/01/2017
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9983995170402771
Metrics
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