Journal article
Low-Cost, High-Pressure-Synthesized Oxygen-Entrapping Materials to Improve Treatment of Solid Tumors
Advanced science, Vol.10(10), e2205995
04/05/2023
DOI: 10.1002/advs.202205995
PMCID: PMC10074083
PMID: 36727291
Abstract
Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric oxygen therapy and microbubble infusion, are utilized to improve the responses to current standard-of-care therapies. However, key obstacles remain, in particular delivery of oxygen at the appropriate dose and with optimal pharmacokinetics. Toward overcoming these hurdles, gas-entrapping materials (GeMs) that are capable of tunable oxygen release are formulated. It is shown that injection or implantation of these materials into tumors can mitigate tumor hypoxia by delivering oxygen locally and that these GeMs enhance responsiveness to radiation and chemotherapy in multiple tumor types. This paper also demonstrates, by comparing an oxygen (O
)-GeM to a sham GeM, that the former generates an antitumorigenic and immunogenic tumor microenvironment in malignant peripheral nerve sheath tumors. Collectively the results indicate that the use of O
-GeMs is promising as an adjunctive strategy for the treatment of solid tumors.
Details
- Title: Subtitle
- Low-Cost, High-Pressure-Synthesized Oxygen-Entrapping Materials to Improve Treatment of Solid Tumors
- Creators
- Jianling Bi - University of IowaEmily Witt - University of IowaVanessa A Voltarelli - Beth Israel Deaconess Medical CenterVivian R Feig - Massachusetts Institute of TechnologyVeena Venkatachalam - Brigham and Women's HospitalHannah Boyce - Massachusetts Institute of TechnologyMegan McGovern - Department of Biomedical Engineering, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USAWade R Gutierrez - Medical Scientist Training Program, University of Iowa, Iowa City, IA, 52242, USAJeffrey D Rytlewski - University of IowaKate R Bowman - Department of Radiation Oncology, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USAAshley C Rhodes - Department of Biomedical Engineering, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USAAustin N Cook - Department of Biomedical Engineering, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USABenjamin N Muller - Massachusetts Institute of TechnologyMatthew G Smith - Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USAAlexis Rebecca Ramos - Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USAHeena Panchal - Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USARebecca D Dodd - University of IowaMichael D Henry - University of IowaAdam Mailloux - Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USAGiovanni Traverso - Massachusetts Institute of TechnologyLeo E Otterbein - Beth Israel Deaconess Medical CenterJames D Byrne - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Advanced science, Vol.10(10), e2205995
- DOI
- 10.1002/advs.202205995
- PMID
- 36727291
- PMCID
- PMC10074083
- NLM abbreviation
- Adv Sci (Weinh)
- eISSN
- 2198-3844
- Grant note
- University of Iowa Hospitals and Clinics Department of Radiation Oncology Start-up Funds Massachusetts Institute of Technology Department of Mechanical Engineering Prostate Cancer Foundation Young Investigator Award NIH T32 CA086862 / Holden Comprehensive Cancer Center Support Grant P30 Holden Comprehensive Cancer Center
- Language
- English
- Electronic publication date
- 02/02/2023
- Date published
- 04/05/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Microbiology and Immunology; Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984363682602771
Metrics
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