Journal article
Low-Intensity Exercise Reverses Chronic Muscle Pain in the Rat in a Naloxone-Dependent Manner
Archives of physical medicine and rehabilitation, Vol.86(9), pp.1736-1740
2005
DOI: 10.1016/j.apmr.2005.03.029
PMID: 16181935
Abstract
Hoeger Bement MK, Sluka KA. Low-intensity exercise reverses chronic muscle pain in the rat in a naloxone-dependent manner.
To determine the effects of low-intensity exercise on chronic muscle pain and potential activation of the endogenous opioid system.
Randomized placebo-controlled trial.
Animal laboratory.
Sixty-three male Sprague-Dawley rats.
Rats performed a low-intensity exercise protocol for 5 consecutive days after the induction of chronic muscle pain. In a separate experiment, naloxone or saline was administered systemically before 5 low-intensity exercise sessions.
Mechanical hyperalgesia was measured using von Frey filaments to determine the mechanical withdrawal threshold.
Low-intensity exercise increased mechanical withdrawal threshold in the chronic muscle pain model. Naloxone attenuated the antihyperalgesic effects of low-intensity exercise.
Low-intensity exercise reversed mechanical hyperalgesia in the chronic muscle pain model through activation of the endogenous opioid system.
Details
- Title: Subtitle
- Low-Intensity Exercise Reverses Chronic Muscle Pain in the Rat in a Naloxone-Dependent Manner
- Creators
- Marie K Hoeger Bement - Physical Therapy Department, Integrative Neuroscience Research Center, College of Health Sciences, Marquette University, Milwaukee, WIKathleen A Sluka - Physical Therapy and Rehabilitation Science Graduate Program, Neuroscience Graduate Program, Pain Research Program, College of Medicine, University of Iowa, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- Archives of physical medicine and rehabilitation, Vol.86(9), pp.1736-1740
- DOI
- 10.1016/j.apmr.2005.03.029
- PMID
- 16181935
- NLM abbreviation
- Arch Phys Med Rehabil
- ISSN
- 0003-9993
- eISSN
- 1532-821X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2005
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984040226802771
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