Journal article
Low-dose aspirin therapy is not a reason for repeating head computed tomographic scans in traumatic brain injury: a prospective study
The Journal of surgical research, Vol.186(1), pp.287-291
01/01/2014
DOI: 10.1016/j.jss.2013.08.009
PMID: 24011918
Abstract
Background: Most studies have categorized all antiplatelet drugs into one category. The aim of our study was to evaluate the utility of repeat head computed tomography (RHCT) and outcomes in patients on low-dose aspirin (acetylsalicylic acid; ASA) therapy.
Methods: Patients with traumatic brain injury with intracranial hemorrhage on initial head computed tomography (CT) were prospectively enrolled. Patients on prehospital low-dose (81 mg) aspirin therapy were matched with patients exclusive of antiplatelet and anticoagulation therapy using propensity score matching in a 1:1 ratio for age, Glasgow Coma Scale, head Abbreviated Injury Scale score, Injury Severity Score, and neurological examination. Outcome measures were progression on RHCT and subsequent neurosurgical intervention.
Results: A total of 144 patients who had intracranial hemorrhage on initial CT scan (ASA group: 72; No-ASA group: 72) were enrolled. The mean age was 72.8 +/- 11.7 years, 59.7% were male, and median head Abbreviated Injury Scale was 3 (2-3). There was no difference in progression on RHCT (25% in ASA versus 16.6% in no-ASA), change in management as a result of RHCT (1.4% versus 1.4%), RHCT as a result of neurological decline (0 versus 1.4%), discharge Glasgow Coma Scale (15 [14-15] versus 15 [14-15]), and mortality (0 versus 1.4%) between the two groups.
Conclusions: Low-dose aspirin therapy is not associated with progression of initial insult on RHCT or clinical deterioration. Prehospital low-dose aspirin therapy as a sole criterion should not warrant a routine repeat head CT in traumatic brain injury. Published by Elsevier Inc.
Details
- Title: Subtitle
- Low-dose aspirin therapy is not a reason for repeating head computed tomographic scans in traumatic brain injury: a prospective study
- Creators
- Bellal Joseph - University of ArizonaHassan Aziz - University of ArizonaViraj Pandit - University of ArizonaNarong Kulvatunyou - University of ArizonaTerence O'Keeffe - University of ArizonaAndrew Tang - University of ArizonaJulie Wynne - University of ArizonaAmmar Hashmi - University of ArizonaGary Vercruysse - University of ArizonaRandall S. Friese - University of ArizonaPeter Rhee - University of Arizona
- Resource Type
- Journal article
- Publication Details
- The Journal of surgical research, Vol.186(1), pp.287-291
- Publisher
- Elsevier
- DOI
- 10.1016/j.jss.2013.08.009
- PMID
- 24011918
- ISSN
- 0022-4804
- eISSN
- 1095-8673
- Number of pages
- 5
- Language
- English
- Date published
- 01/01/2014
- Academic Unit
- Surgery
- Record Identifier
- 9984701641702771
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