Low-fat dietary pattern and breast cancer mortality by metabolic syndrome components: a secondary analysis of the Women's Health Initiative (WHI) randomised trial

Kathy Pan; Aaron K Aragaki; Marian L Neuhouser; Michael S Simon; Juhua Luo; Bette Caan; Linda Snetselaar; Joanne E Mortimer; JoAnn E Manson; Candyce Kroenke; Dorothy Lane; Kerryn Reding; Thomas E Rohan; Rowan T Chlebowski

doi:10.1038/s41416-021-01379-w

Back

Low-fat dietary pattern and breast cancer mortality by metabolic syndrome components: a secondary analysis of the Women's Health Initiative (WHI) randomised trial

Journal article

Open access

Peer reviewed

Low-fat dietary pattern and breast cancer mortality by metabolic syndrome components: a secondary analysis of the Women's Health Initiative (WHI) randomised trial

Kathy Pan, Aaron K Aragaki, Marian L Neuhouser, Michael S Simon, Juhua Luo, Bette Caan, Linda Snetselaar, Joanne E Mortimer, JoAnn E Manson, Candyce Kroenke, …

British journal of cancer, Vol.125(3), pp.372-379

05/18/2021

DOI: 10.1038/s41416-021-01379-w

PMCID: PMC8329224

PMID: 34006923

Files and links (1)

url

https://doi.org/10.1038/s41416-021-01379-wView

Published (Version of record) Open Access

Abstract

In the Women's Health Initiative (WHI) dietary modification (DM) randomised trial, the low-fat dietary intervention reduced deaths from breast cancer (P = 0.02). Extending these findings, secondary analysis examined dietary intervention influence on breast cancer mortality by metabolic syndrome (MS) components. In total, 48,835 postmenopausal women with no prior breast cancer were randomised to a low-fat dietary intervention or comparison groups. Four MS components were determined at entry in 45,833 participants: (1) high waist circumference, (2) high blood pressure, (3) high cholesterol and (4) diabetes history. Forest plots of hazard ratios (HRs) were generated with P-values for interaction between randomisation groups and MS component score. Primary outcome was death from breast cancer by metabolic syndrome score. HRs and 95% confidence intervals (CI) for dietary intervention influence on death from breast cancer were with no MS components (n = 10,639), HR 1.09, 95% CI 0.63-1.87; with 1-2 MS components (n = 30,948), HR 0.80, 95% CI 0.62-1.02; with 3-4 MS components (n = 4,246), HR 0.31, 95% CI 0.14-0.69 (interaction P = 0.01). While postmenopausal women with 3-4 MS components were at higher risk of death from breast cancer, those randomised to a low-fat dietary intervention more likely had reduction in this risk. ClinicalTrials.gov (NCT00000611).

Details

Title: Subtitle: Low-fat dietary pattern and breast cancer mortality by metabolic syndrome components: a secondary analysis of the Women's Health Initiative (WHI) randomised trial
Creators: Kathy Pan - Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. kathyjpan@gmail.com
Aaron K Aragaki - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Marian L Neuhouser - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Michael S Simon - Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
Juhua Luo - University of Indiana, Bloomington, IN, USA
Bette Caan - Kaiser Permanente Northern California Division of Research, Oakland, CA, USA
Linda Snetselaar - University of Iowa, Bloomington, IN, USA
Joanne E Mortimer - City of Hope National Medical Center, Duarte, CA, USA
JoAnn E Manson - Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA
Candyce Kroenke - Kaiser Permanente Northern California Division of Research, Oakland, CA, USA
Dorothy Lane - State University of New York at Stony Brook, Stony Brook, NY, USA
Kerryn Reding - Fred Hutchinson Cancer Research Center & University of Washington, School of Nursing, Seattle, WA, USA
Thomas E Rohan - Albert Einstein College of Medicine, Bronx, NY, USA
Rowan T Chlebowski - Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA
Resource Type: Journal article
Publication Details: British journal of cancer, Vol.125(3), pp.372-379
DOI: 10.1038/s41416-021-01379-w
PMID: 34006923
PMCID: PMC8329224
NLM abbreviation: Br J Cancer
ISSN: 0007-0920
eISSN: 1532-1827
Language: English
Date published: 05/18/2021
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984215042302771

Metrics

13 Record Views

22 Times Cited - Web of Science