Journal article
Low-fat dietary pattern and dietary advanced glycation end-products intake: a secondary analysis of the Women's Health Initiative randomized trial
British journal of cancer
07/28/2026
DOI: 10.1038/s41416-026-03514-x
PMID: 42521771
Abstract
In the Women's Health Initiative (WHI) Dietary Modification (DM) randomized trial, a low-fat dietary pattern intervention reduced breast cancer mortality (P = 0.02). Higher dietary advanced glycation end-products (dAGE) may be associated with higher breast cancer incidence. In this report, we examined whether the WHI dietary intervention influenced dAGE consumption.
Of 48,835 postmenopausal women randomized (40:60) to dietary intervention versus usual diet comparison, 40,209 had food frequency questionnaires at baseline, and serially through 5-7 years, which were used to estimate dAGE scores (kilo Unit/1000 kilocalories [kU/1000 kcal]) using a commonly referenced database. Multivariate regressions with repeated dAGE measures were examined by randomization group.
Baseline mean dAGE scores were similar for intervention (7542 kU/1000 kcal, standard deviation (SD) = 912) and comparison (7514 kU/1000 kcal, SD = 917) groups. Through 5-7 years, dAGE scores were persistently lower in intervention versus comparison groups (mean range 5361-6236 kU/1000 kcal versus 7159-7669 kU/1000 kcal (P < 0.0001).
The WHI low-fat dietary pattern intervention substantially reduced dAGE consumption.
NCT00000611; Date: 10/28/1999.
Details
- Title: Subtitle
- Low-fat dietary pattern and dietary advanced glycation end-products intake: a secondary analysis of the Women's Health Initiative randomized trial
- Creators
- Margaret S Pichardo - Penn Center for AIDS ResearchRebecca P Hunt - Fred Hutch Cancer CenterLindsay L Peterson - Washington University in St. LouisKathy Pan - Kaiser PermanenteMace Coday - University of Tennessee Health Science CenterSu Yon Jung - University of California, Los AngelesLinda Snetselaar - University of IowaMarian L Neuhouser - Fred Hutch Cancer CenterSusan E Steck - University of South CarolinaFred K Tabung - The Ohio State UniversityNazmus Saquib - Sulaiman Al Rajhi CollegesJoAnn E Manson - Brigham and Women's HospitalRowan T Chlebowski - The Lundquist Institute
- Resource Type
- Journal article
- Publication Details
- British journal of cancer
- DOI
- 10.1038/s41416-026-03514-x
- PMID
- 42521771
- ISSN
- 0007-0920
- eISSN
- 1532-1827
- Publisher
- Springer Nature
- Grant note
- National Heart, Lung, and Blood Institute (NHLBI) National Institutes of Health, U.S. Department of Health and Human Services: 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, 75N92021D00005 National Institutes of Health/National Cancer Institute Loan Repayment Program Award: LRP0000062905 Women's Health Institute (WHI) Project Office at the National Heart, Lung, and Blood Institute (NHLBI)
The WHI program is funded by the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, U.S. Department of Health and Human Services through contracts 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, 75N92021D00005. MP was funded by the National Institutes of Health/National Cancer Institute Loan Repayment Program Award #LRP0000062905. The Women's Health Institute (WHI) Project Office at the National Heart, Lung, and Blood Institute (NHLBI), the Sponsor, reviewed and approved the final manuscript but had no other role in the preparation of this report. Decisions concerning study design, data collection and analysis, interpretation of the results, the preparation of the manuscript, or the decision to submit the manuscript for publication resided with committees comprised of WHI investigators that included NHLBI representatives.
- Language
- English
- Electronic publication date
- 07/28/2026
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9985215017902771
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