Journal article
Low-fat vs. high-fat bedtime snacks in children and adolescents with type 1 diabetes
Pediatric diabetes, Vol.9(4pt1), pp.320-325
Submitted 12 November 2007. Accepted for publication 8 February 2008
08/2008
DOI: 10.1111/j.1399-5448.2008.00393.x
PMCID: PMC2593894
PMID: 18768036
Abstract
Objective: The purpose of this study was to determine whether, in a group of children with type 1 diabetes using insulin pump, a prebedtime snack with a relatively high fat content provides greater protection from nocturnal hypoglycemia than a snack containing the same amount of carbohydrate and protein but a lower fat content.
Research design and methods: Ten subjects, aged 6 to <18 yr, in a trial evaluating the Abbott Navigator glucose sensor, agreed to this ancillary study. On 12 or more separate nights, each subject was randomized by a Web site to a carbohydrate–low-fat (30 g CHO, 2.5 g protein, and 1.3 g fat; 138 kcal) snack or a carbohydrate–high-fat (30 g CHO, 2 g protein, and 20 g fat; 320 kcal) snack. Subjects used their usual evening snack algorithm to determine the size (in 15-g carbohydrate increments) and insulin dosage.
Results: Average glucose on 128 valid study nights before snack was similar in both groups. The proportion of nights with hypoglycemia (a sensor or meter glucose value ≤70 mg/dL) was similar in both groups (19% high fat vs. 20% low fat), as was the proportion of nights with hyperglycemia (a glucose ≥200 mg/dL and at least 50 mg/dL above baseline, 35% high fat vs. 30% low fat).
Conclusions: There were no statistical differences between the high- and low-fat snacks on the frequency of hyperglycemia or hypoglycemia. This study highlights the feasibility of web-based research in patients’ home environment.
Details
- Title: Subtitle
- Low-fat vs. high-fat bedtime snacks in children and adolescents with type 1 diabetes
- Creators
- Darrell Wilson - Division of Pediatric Endocrinology and Diabetes, Stanford University, Stanford, CA, USAH Peter Chase - Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver, CO, USACraig Kollman - Jaeb Center for Health Research, Tampa, FL, USADongyuan Xing - Jaeb Center for Health Research, Tampa, FL, USAKimberly Caswell - Division of Pediatric Endocrinology and Diabetes, Stanford University, Stanford, CA, USAMichael Tansey - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USALarry Fox - Nemours Children's Clinic, Jacksonville, FL, USAStuart Weinzimer - Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USARoy Beck - Jaeb Center for Health Research, Tampa, FL, USAKatrina Ruedy - Jaeb Center for Health Research, Tampa, FL, USAWilliam Tamborlane - Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USADiabetes Research In Children Network (DirecNet) Study Group
- Resource Type
- Journal article
- Publication Details
- Pediatric diabetes, Vol.9(4pt1), pp.320-325
- Edition
- Submitted 12 November 2007. Accepted for publication 8 February 2008
- DOI
- 10.1111/j.1399-5448.2008.00393.x
- PMID
- 18768036
- PMCID
- PMC2593894
- NLM abbreviation
- Pediatr Diabetes
- ISSN
- 1399-543X
- eISSN
- 1399-5448
- Publisher
- Blackwell Publishing Ltd
- Number of pages
- 6
- Language
- English
- Date published
- 08/2008
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093363702771
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