Journal article
Low indoleamine 2, 3 dioxygenase (IDO) activity is associated with psycho-obstetric risk
Pregnancy hypertension, Vol.35, pp.12-18
03/2024
DOI: 10.1016/j.preghy.2023.11.008
PMCID: PMC11003651
PMID: 38064980
Abstract
Preeclampsia and depression in pregnancy are among the most prevalent obstetric disorders with no known cures. While depression and preeclampsia each increase risk for the other, shared mechansisms are unclear. One possibility is low levels of Indoleamine 2,3 dioxygenase (IDO), which links immune dysregulation and oxidative arterial damage resulting in poor vascular function in both preeclampsia and depression. We hypothesized low circulating IDO activity levels in pregnancy would correspond to poor vascular function and depression symptoms.
In this nested case-control study, clinical, demographic, and biologic data from a cohort of pregnant women recruited to longitudinal studies measuring noninvasive vascular function and circulating factors were analyzed.
IDO activity across all three trimesters of pregnancy was measured using a colorimetric assay. Carotid-femoral pulse wave velocity (cfPWV), a measure of arterial stiffness, was also assessed throughout gestation by non-invasive applanation tonometry. Depression symptoms were assessed in pregnancy via the validated patient health questionnaire 9 (PHQ9).
Participants with low second and third trimester IDO activity had significantly decreased cfPWV. This association remained statistically significant when controlled for confounders such as BMI and chronic hypertension in the third but not second trimester. While PHQ9 scores were not associated with cfPWV differences, IDO activity was lower in moderate and severely depressed relative to non-depressed pregnant individuals.
These results implicate IDO in arterial stiffness and depression symptoms, suggesting that decreased IDO may be a central target for improved psycho-obstetric health.
Details
- Title: Subtitle
- Low indoleamine 2, 3 dioxygenase (IDO) activity is associated with psycho-obstetric risk
- Creators
- Serena Gumusoglu - University of IowaCasee R Meincke - University of IowaMichaela Kiel - University of IowaAlexandria Betz - Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242, United StatesVirginia Nuckols - University of IowaLyndsey DuBose - University of IowaJessica SteideleEileen Sweezer - Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242, United StatesDonna Santillan - University of IowaAmy K Stroud - University of IowaGary L Pierce - University of IowaMark K Santillan - Department of Health and Human Physiology, University of Iowa, Iowa City, IA 52242, United States. Electronic address: mark-santillan@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Pregnancy hypertension, Vol.35, pp.12-18
- DOI
- 10.1016/j.preghy.2023.11.008
- PMID
- 38064980
- PMCID
- PMC11003651
- NLM abbreviation
- Pregnancy Hypertens
- eISSN
- 2210-7797
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: 5T32HL007121-45, HD000849, HD089940, P50HD10355601A1, RR024980, 3UL1TR002537; DOI: 10.13039/100000968, name: American Heart Association
- Language
- English
- Electronic publication date
- 12/07/2023
- Date published
- 03/2024
- Academic Unit
- Iowa Neuroscience Institute; Obstetrics and Gynecology; Dental Research; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984530394902771
Metrics
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