Journal article
Lowdenic acid: A new antifungal polyketide-derived metabolite from a new fungicolous Verticillium sp
Journal of natural products (Washington, D.C.), Vol.66(9), pp.1259-1262
2003
DOI: 10.1021/np0301285
PMID: 14510612
Abstract
Lowdenic acid (1), a new antifungal metabolite with an unusual structure and a mixed biogenetic origin, has been obtained from nonsporulating cultures of a previously undescribed Verticillium sp. (MYC-406 = NRRL 29280) that was isolated as a colonist of polypore basidiomata. The gross structure of 1 was proposed by analysis of NMR data and confirmed by X-ray diffraction analysis, which enabled assignment of relative stereochemistry. Compound 1 occurs as an equilibrium E/Z mixture. The known antifungal metabolite canescin A (2) was also isolated.
Details
- Title: Subtitle
- Lowdenic acid: A new antifungal polyketide-derived metabolite from a new fungicolous Verticillium sp
- Creators
- Rihab F Angawi - Department of Chemistry, Faculty of Science, King Abdul-Aziz University, Jeddah, Saudi ArabiaDale C Swenson - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United StatesJames B Gloer - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United StatesDonald T Wicklow - Mycotoxin Research Unit, National Center for Agricultural Utilization Research, USDA, Peoria, Illinois 61604, United States
- Resource Type
- Journal article
- Publication Details
- Journal of natural products (Washington, D.C.), Vol.66(9), pp.1259-1262
- Publisher
- American Society of Pharmacognosy
- DOI
- 10.1021/np0301285
- PMID
- 14510612
- ISSN
- 0163-3864
- eISSN
- 1520-6025
- Language
- English
- Date published
- 2003
- Academic Unit
- Chemistry
- Record Identifier
- 9984216715802771
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