Lower TSH and higher T4 levels are associated with current depressive syndrome in young adults

V Forman-Hoffman; R A Philibert

doi:10.1111/j.1600-0447.2005.00703.x

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Lower TSH and higher T4 levels are associated with current depressive syndrome in young adults

Journal article

Peer reviewed

Lower TSH and higher T4 levels are associated with current depressive syndrome in young adults

V Forman-Hoffman and R A Philibert

Acta psychiatrica Scandinavica, Vol.114(2), pp.132-139

08/2006

DOI: 10.1111/j.1600-0447.2005.00703.x

PMID: 16836601

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Abstract

The relationship of individual thyroid function indices to depression in those without a history of prior thyroid dysfunction is uncertain. We examined the relationship between thyroid-stimulating hormone (TSH) and thyroxine (T4) levels and current or lifetime history of depressive symptoms using information from 6869 participants, aged 17-39 years, in the Third National Health and Nutrition Examination Survey without history of thyroid-related illness. We found that lower TSH and higher T4 levels were associated with current depressive syndrome in men, but only higher T4 levels correlated with current depressive syndrome in women. Lifetime depressive syndrome was associated with neither TSH level nor T4 levels in men or women. These findings suggest that transient or 'state dependent' changes are associated with depression in those without a history of thyroid illness. Further studies to discern whether these depression-associated changes represent distinct endophenotypes of depression should be encouraged.

Severity of Illness Index

Demography

Cross-Sectional Studies

Humans

Depressive Disorder - diagnosis

Thyroxine - blood

Male

Adolescent

Sex Distribution

Adult

Female

Depressive Disorder - epidemiology

Depressive Disorder - blood

Thyrotropin - blood

Details

Title: Subtitle: Lower TSH and higher T4 levels are associated with current depressive syndrome in young adults
Creators: V Forman-Hoffman - Department of Internal Medicine, The University of Iowa, Iowa City, IA 52242-1000, USA
R A Philibert
Resource Type: Journal article
Publication Details: Acta psychiatrica Scandinavica, Vol.114(2), pp.132-139
DOI: 10.1111/j.1600-0447.2005.00703.x
PMID: 16836601
NLM abbreviation: Acta Psychiatr Scand
ISSN: 0001-690X
eISSN: 1600-0447
Publisher: United States
Grant note: K08MH064714 / NIMH NIH HHS
Language: English
Date published: 08/2006
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Epidemiology; Iowa Neuroscience Institute
Record Identifier: 9984003402002771

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