Lower limit of normal based spirometric abnormalities associated with radiographic abnormality in an elderly cohort at low risk for exposure

Marek A Mikulski; Alicia K Gerke; John D Newell; Ann M Murray; Carmen J Smith; Laurence J Fuortes

doi:10.1080/10773525.2016.1176328

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Lower limit of normal based spirometric abnormalities associated with radiographic abnormality in an elderly cohort at low risk for exposure

Journal article

Open access

Peer reviewed

Lower limit of normal based spirometric abnormalities associated with radiographic abnormality in an elderly cohort at low risk for exposure

Marek A Mikulski, Alicia K Gerke, John D Newell, Ann M Murray, Carmen J Smith and Laurence J Fuortes

International journal of occupational and environmental health, Vol.22(2), pp.121-127

04/02/2016

DOI: 10.1080/10773525.2016.1176328

PMCID: PMC4984964

PMID: 27142581

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Abstract

Background: Although the relation between radiographic abnormalities and spirometric impairment in people with asbestosis has been studied extensively, the extent of spirometric impairment associated with milder radiographic abnormalities is not established. Objective: To test associations between mild radiographic abnormalities and Lower Limit of Normal (LLN)-based spirometry interpretation. Methods: Spirometry and CXRs were collected for 1,026 at low risk of exposure to pneumoconiotic agents participants in a medical screening program. Results: Individuals with each type of isolated or combined International Labour Organization (ILO) abnormalities had up to over sixfold statistically significant increase in odds of LLN-based restrictive pattern physiology (OR = 1.96, 95%CI 1.03-3.73 for parenchymal to OR = 6.09, 95%CI 1.94-19.10 for parenchymal and pleural) compared to those with normal films. Conclusions: The findings from this study confirm the association of mild profusion abnormalities with clinically relevant, LLN-based lung function abnormalities.

Spirometry

Lower limit of normal

Pneumoconiosis

Spirometric abnormalities

ILO

Details

Title: Subtitle: Lower limit of normal based spirometric abnormalities associated with radiographic abnormality in an elderly cohort at low risk for exposure
Creators: Marek A Mikulski - Department of Occupational and Environmental Health, College of Public Health, The University of Iowa
Alicia K Gerke - Department of Internal Medicine, The University of Iowa Hospitals and Clinics
John D Newell - Department of Radiology, The University of Iowa Hospitals and Clinics
Ann M Murray - Roy J. and Lucille Carver College of Medicine, The University of Iowa
Carmen J Smith - Department of Biostatistics, College of Public Health, The University of Iowa
Laurence J Fuortes - Department of Occupational and Environmental Health, College of Public Health, The University of Iowa
Resource Type: Journal article
Publication Details: International journal of occupational and environmental health, Vol.22(2), pp.121-127
DOI: 10.1080/10773525.2016.1176328
PMID: 27142581
PMCID: PMC4984964
NLM abbreviation: Int J Occup Environ Health
ISSN: 1077-3525
eISSN: 2049-3967
Publisher: Taylor & Francis
Grant note: DE-FC01-06EH06020 / U.S. Department of Energy (10.13039/100000015)
Language: English
Date published: 04/02/2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Pulmonary, Critical Care, and Occupational Medicine; Occupational and Environmental Health; Internal Medicine
Record Identifier: 9984094339002771

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