Journal article
Lower might be better - It matters how you get there, and in whom
European heart journal, Vol.37(17), pp.1380-1383
2016
DOI: 10.1093/eurheartj/ehw102
PMID: 27026749
Abstract
This editorial refers to ‘Percent reduction in LDL cholesterol following high-intensity statin therapy: potential implications for guidelines and for the prescription of emerging lipid-lowering agents’[†][1], by P.M. Ridker et al ., on page 1373. Cholesterol treatment guidelines will continue evolving as new evidence emerges from randomized trials. Statins have been shown to reduce cardiovascular events in progressively lower risk patient populations with progressively lower entry and on-treatment LDL-cholesterol (LDC-C) levels. This evidence was interpreted to support further reductions in LDL-C treatment goals.1,2 When trials demonstrated that high intensity statins reduced cardiovascular events more than moderate intensity statins, some guidelines recommended a ≥50% LDL-C reduction as an alternative treatment objective for high risk patients, reflecting the average reduction in LDL-C expected from high intensity statins.2–4 However, substantial heterogeneity in treatment response has been reported. In a meta-analysis of eight cardiovascular outcomes trials by Boekholdt et al ., approximately half of patients obtained a ≥50% reduction in LDL-C with a high intensity statin.5 Greater relative risk reductions (RRRs) occurred with progressively lower achieved LDL-C, with the greatest RRR when LDL-C was 80% reductions in LDL-C, with 46% experiencing a ≥50% reduction in LDL-C. Heterogeneity in … [1]: #fn-2
Details
- Title: Subtitle
- Lower might be better - It matters how you get there, and in whom
- Creators
- Jennifer G Robinson
- Resource Type
- Journal article
- Publication Details
- European heart journal, Vol.37(17), pp.1380-1383
- DOI
- 10.1093/eurheartj/ehw102
- PMID
- 27026749
- ISSN
- 1522-9645
- eISSN
- 1522-9645
- Language
- English
- Date published
- 2016
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983996086402771
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