Lower motor neuron disease in a patient with autoantibodies against Gal(beta 1-3)GalNAc in gangliosides GM1 and GD1b: improvement following immunotherapy

M E Shy; T Heiman-Patterson; G J Parry; A Tahmoush; V A Evans; P K Schick

doi:10.1212/WNL.40.5.842

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Lower motor neuron disease in a patient with autoantibodies against Gal(beta 1-3)GalNAc in gangliosides GM1 and GD1b: improvement following immunotherapy

Journal article

Peer reviewed

Lower motor neuron disease in a patient with autoantibodies against Gal(beta 1-3)GalNAc in gangliosides GM1 and GD1b: improvement following immunotherapy

M E Shy, T Heiman-Patterson, G J Parry, A Tahmoush, V A Evans and P K Schick

Neurology, Vol.40(5), pp.842-844

05/1990

DOI: 10.1212/WNL.40.5.842

PMID: 2330115

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Abstract

We followed a patient with a lower motor neuron form of motor neuron disease whose neurologic disorder improved following immunotherapy. The patient did not have an M protein but did have IgM antibodies to ganglioside GM1 detectable at serum titers of 1:2,000 by ELISA. These antibodies were found only in the IgM fraction with lambda light chains and immunoreacted with GD1b and Gal (beta 1-3) GalNAc.

Neuromuscular Diseases - immunology

Chromatography, High Pressure Liquid - methods

Enzyme-Linked Immunosorbent Assay

Motor Neurons - immunology

Humans

Immunoglobulin M - analysis

Male

Gangliosides - immunology

Neuromuscular Diseases - therapy

Disaccharides - immunology

G(M1) Ganglioside - immunology

Immunotherapy

Adult

Antigens, Tumor-Associated, Carbohydrate

Autoantibodies - analysis

Details

Title: Subtitle: Lower motor neuron disease in a patient with autoantibodies against Gal(beta 1-3)GalNAc in gangliosides GM1 and GD1b: improvement following immunotherapy
Creators: M E Shy - Department of Neurology, Thomas Jefferson University, Philadelphia
T Heiman-Patterson
G J Parry
A Tahmoush
V A Evans
P K Schick
Resource Type: Journal article
Publication Details: Neurology, Vol.40(5), pp.842-844
Publisher: United States
DOI: 10.1212/WNL.40.5.842
PMID: 2330115
ISSN: 0028-3878
eISSN: 1526-632X
Grant note: K08 NSO126-02 / NINDS NIH HHS
Language: English
Date published: 05/1990
Academic Unit: Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
Record Identifier: 9984020896202771

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