Journal article
Lubeluzole and conditioned learning after cerebral ischemia
Experimental brain research, Vol.152(3), pp.329-334
10/2003
DOI: 10.1007/s00221-003-1539-9
PMID: 12904938
Abstract
Lubeluzole [S-4-(2-benzothiazolylmethylamino)-α-((3,4-difluorophenoxy)methyl)-1-piperidineethanol] reduces the severity of cerebral injury in animal models of brain ischemia. Its beneficial effects may include decreased concentration of extracellular glutamate, blockade of sodium and calcium channels, and attenuation of nitric oxide-mediated neuronal death. Previous studies have shown that global cerebral ischemia in rabbits impaired the subsequent acquisition of a trace-conditioned eyeblink reflex. Here, we examined the effect of preischemic treatment with lubeluzole on the acquisition of a trace-conditioned eyeblink response after 6.5 min of global cerebral ischemia. Three groups of rabbits underwent cerebral ischemia: one group underwent ischemia alone (I) and two groups underwent ischemia and also received lubeluzole (L1, 1.25 mg/kg, and L2, 2.5 mg/kg). All animals were subsequently trained using classical trace conditioning. Each training session consisted of the presentation of the conditioned stimulus (an 85-dB, 6-kHz auditory tone lasting for 100 ms) followed by a trace interval (a period of 300 ms during which no external stimulus was delivered) followed finally by the delivery of the unconditioned stimulus (a 150-ms puff of air directed at the cornea). We found that animals receiving preischemic administration of 1.25 mg/kg of lubeluzole demonstrated a significantly improved acquisition of the trace-conditioned reflex as compared to animals that did not receive lubeluzole. This finding demonstrates improved long-term neurobehavioral outcome with preischemic administration of 1.25 mg/kg of lubeluzole.
Details
- Title: Subtitle
- Lubeluzole and conditioned learning after cerebral ischemia
- Creators
- Rashmi Mueller - Department of Anesthesiology University of Texas Medical Branch 301 University Boulevard Galveston TX 77555–0591 USADonald Deyo - Department of Anesthesiology University of Texas Medical Branch 301 University Boulevard Galveston TX 77555–0591 USADavid Brantley - Department of Anesthesiology University of Texas Medical Branch 301 University Boulevard Galveston TX 77555–0591 USAJohn Disterhoft - Department of Physiology, The Feinberg School of Medicine Northwestern University Evanston IL 60611 USAMark Zornow - Department of Anesthesiology University of Texas Medical Branch 301 University Boulevard Galveston TX 77555–0591 USA
- Resource Type
- Journal article
- Publication Details
- Experimental brain research, Vol.152(3), pp.329-334
- Publisher
- Springer-Verlag; Berlin/Heidelberg
- DOI
- 10.1007/s00221-003-1539-9
- PMID
- 12904938
- ISSN
- 0014-4819
- eISSN
- 1432-1106
- Language
- English
- Date published
- 10/2003
- Academic Unit
- Anesthesia
- Record Identifier
- 9984006345202771
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