Journal article
Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus
Immunity (Cambridge, Mass.), Vol.39(5), pp.939-948
11/14/2013
DOI: 10.1016/j.immuni.2013.09.013
PMCID: PMC3872058
PMID: 24238342
Abstract
Inducing memory CD8+ T cells specific for conserved antigens from influenza A virus (IAV) is a potential strategy for broadly protective vaccines. Here we show that memory CD8+ T cells in the airways played an important role in early control of IAV. Expression of the chemokine receptor CXCR3 was critical for memory CD8+ T cells to populate the airways during the steady state and vaccination approaches were designed to favor the establishment of memory CD8+ T cells in the airways. Specifically, we found that interleukin-12 (IL-12) signaling shortly after immunization limited CXCR3 expression on memory CD8+ T cells. Neutralization of IL-12 or adjuvants that did not induce high amounts of IL-12 enhanced CXCR3 expression, sustained airway localization of memory CD8+ T cells, and resulted in superior protection against IAV.
•Memory CD8+ T cells in airways provide rapid protection against influenza A virus•CXCR3hi memory CD8+ T cells accumulate in the airways during steady-state conditions•IL-12 signaling reduces CXCR3 and airway localization of memory CD8+ T cells•Limiting IL-12 enhances memory CD8+ T cells in airways and immunity to IAV
Details
- Title: Subtitle
- Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus
- Creators
- Bram Slütter - Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USALecia L Pewe - Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USASusan M Kaech - Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USAJohn T Harty - Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.39(5), pp.939-948
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.immuni.2013.09.013
- PMID
- 24238342
- PMCID
- PMC3872058
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Language
- English
- Date published
- 11/14/2013
- Academic Unit
- Pathology
- Record Identifier
- 9984047742002771
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