Journal article
Lung Cancer Screening and Incidental Findings: A Research Agenda An Official American Thoracic Society Research Statement
American journal of respiratory and critical care medicine, Vol.211(3), pp.436-451
03/01/2025
DOI: 10.1164/rccm.202501-0011ST
PMID: 39928329
Abstract
Background: Lung cancer screening with low-dose computed tomography (LDCT) may uncover incidental findings (IFs) unrelated to lung cancer. There may be potential benefits from identifying clinically significant IFs that warrant intervention and potential harms related to identifying IFs that are not clinically significant but may result in additional evaluation, clinician effort, patient anxiety, complications, and excess cost. Objectives: To identify knowledge and research gaps and develop and prioritize research questions to address the approach to and management of IFs. Methods: We convened a multidisciplinary panel to review the available literature on IFs detected in lung cancer screening LDCT examinations, focusing on variability and standardizing reporting, management of IFs, and evaluation of the benefits and harms of IFs, particularly cardiovascular-related IFs. We used a three-round modified Delphi process to prioritize research questions. Results: This statement identifies knowledge gaps in 1) reporting of IFs, 2) management of IFs, and 3) identifying and reporting coronary artery calcification found on lung cancer screening LDCT. Finally, we present the panel's initial 36 research questions and the final 20 prioritized questions. Conclusions: This statement provides a prioritized research agenda to further efforts focused on evaluating, managing, and increasing awareness of IFs in lung cancer screening.
Details
- Title: Subtitle
- Lung Cancer Screening and Incidental Findings: A Research Agenda An Official American Thoracic Society Research Statement
- Creators
- Louise M. Henderson - University of North Carolina at Chapel HillRoger Y. Kim - University of Pennsylvania Health SystemNichole T. Tanner - Medical University of South CarolinaEmily B. Tsai - Stanford UniversityAbbie Begnaud - University of MinnesotaFarouk Dako - University of PennsylvaniaMichael Gieske - St. Elizabeth HealthcareKimberly Kallianos - University of California, San FranciscoIlana Richman - Yale UniversityLori C. Sakoda - Kaiser PermanenteRonald G. Schwartz - University of Rochester Medical CenterJoseph Yeboah - Atrium Health Wake Forest BaptistKwun M. Fong - The University of QueenslandStephen Lam - University of British ColumbiaPyng Lee - National University Health SystemMary Pasquinelli - University of Illinois ChicagoRobert A. Smith - American Cancer SocietyMatthew Triplette - University of WashingtonLynn T. Tanoue - Yale UniversityM. Patricia Rivera - University of Rochester Medical CenterAmerican Thoracic Society Assembly on Thoracic Oncology
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.211(3), pp.436-451
- DOI
- 10.1164/rccm.202501-0011ST
- PMID
- 39928329
- ISSN
- 1073-449X
- eISSN
- 1535-4970
- Publisher
- Amer Thoracic Soc
- Number of pages
- 16
- Grant note
- American Thoracic Society
- Language
- English
- Date published
- 03/01/2025
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985179800402771
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