Journal article
Lung Cancer Screening and Smoking Cessation Clinical Trials SCALE (Smoking Cessation within the Context of Lung Cancer Screening) Collaboration
American journal of respiratory and critical care medicine, Vol.197(2), pp.172-182
01/15/2018
DOI: 10.1164/rccm.201705-0909CI
PMID: 28977754
Abstract
National recommendations for lung cancer screening for former and current smokers aged 55–80 years with a 30–pack-year smoking history create demand to implement efficient and effective systems to offer smoking cessation on a large scale. These older, high-risk smokers differ from participants in past clinical trials of behavioral and pharmacologic interventions for tobacco dependence. There is a gap in knowledge about how best to design systems to extend reach and treatments to maximize smoking cessation in the context of lung cancer screening. Eight clinical trials, seven funded by the National Cancer Institute and one by the Veterans Health Administration, address this gap and form the SCALE (Smoking Cessation within the Context of Lung Cancer Screening) collaboration. This paper describes methodological issues related to the design of these clinical trials: clinical workflow, participant eligibility criteria, screening indication (baseline or annual repeat screen), assessment content, interest in stopping smoking, and treatment delivery method and dose, all of which will affect tobacco treatment outcomes. Tobacco interventions consider the “teachable moment” offered by lung cancer screening, how to incorporate positive and negative screening results, and coordination of smoking cessation treatment with clinical events associated with lung cancer screening. Unique data elements, such as perceived risk of lung cancer and costs of tobacco treatment, are of interest. Lung cancer screening presents a new and promising opportunity to reduce morbidity and mortality resulting from lung cancer that can be amplified by effective smoking cessation treatment. SCALE teamwork and collaboration promise to maximize knowledge gained from the clinical trials.
Details
- Title: Subtitle
- Lung Cancer Screening and Smoking Cessation Clinical Trials SCALE (Smoking Cessation within the Context of Lung Cancer Screening) Collaboration
- Creators
- Anne M. Joseph - University of Minnesota Medical CenterAlexander J. Rothman - University of MinnesotaDaniel Almirall - University of MichiganAbbie Begnaud - University of Minnesota Medical CenterCaroline Chiles - Atrium Health Wake Forest BaptistPaul M. Cinciripini - The University of Texas MD Anderson Cancer CenterSteven S. Fu - University of Minnesota Medical CenterAmanda L. Graham - Truth InitiativeBruce R. Lindgren - Southern California Clinical and Translational Science InstituteAnne C. Melzer - University of Minnesota Medical CenterJamie S. Ostroff - Memorial Sloan Kettering Cancer CenterElizabeth L. Seaman - National Cancer InstituteKathryn L. Taylor - Georgetown University Medical CenterBenjamin A. Toll - Medical University of South CarolinaSteven B. Zeliadt - University of WashingtonDavid M. Vock - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.197(2), pp.172-182
- DOI
- 10.1164/rccm.201705-0909CI
- PMID
- 28977754
- NLM abbreviation
- Am J Respir Crit Care Med
- ISSN
- 1073-449X
- eISSN
- 1535-4970
- Number of pages
- 11
- Grant note
- R01 CA207228 / National Institutes of Health (100000002) Health Services Research and Development (http://data.elsevier.com/vocabulary/SciValFunders/100007217) U.S. Department of Veterans Affairs Health Services Research and Development R01 CA196873 / National Institutes of Health (100000002) 16-071; PPO-14-130 / Health Services Research and Development (http://data.elsevier.com/vocabulary/SciValFunders/100007217) R01 CA207158 / National Institutes of Health (100000002) R01 CA207442 / National Institutes of Health (100000002) P30CA008748; R01 CA196873; R01 CA204222; R01 CA207048; R01 CA207078; R01 CA207158; R01 CA207228; R01 CA207229; R01 CA207442 / National Institutes of Health (http://data.elsevier.com/vocabulary/SciValFunders/100000002) R01 CA207078 / National Institutes of Health (100000002) R01 CA207229 / National Institutes of Health (100000002)
- Language
- English
- Date published
- 01/15/2018
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985179908602771
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