Journal article
Lung Mass in Smokers
Academic radiology, Vol.24(4), pp.386-392
04/2017
DOI: 10.1016/j.acra.2016.10.011
PMCID: PMC5600161
PMID: 27940230
Abstract
Emphysema is characterized by airspace dilation, inflammation, and irregular deposition of elastin and collagen in the interstitium. Computed tomographic studies have reported that lung mass (LM) may be increased in smokers, a finding attributed to inflammatory and parenchymal remodeling processes observed on histopathology. We sought to examine the epidemiologic and clinical associations of LM in smokers.
Baseline epidemiologic, clinical, and computed tomography (CT) data (n = 8156) from smokers enrolled into the COPDGene Study were analyzed. LM was calculated from the CT scan. Changes in lung function at 5 years' follow-up were available from 1623 subjects. Regression analysis was performed to assess for associations of LM with forced expiratory volume in 1 second (FEV1) and FEV1 decline.
Subjects with Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1 chronic obstructive pulmonary disease had greater LM than either smokers with normal lung function or those with GOLD 2–4 chronic obstructive pulmonary disease (P < 0.001 for both comparisons). LM was predictive of the rate of the decline in FEV1 (decline per 100 g, −4.7 ± 1.7 mL/y, P = 0.006).
Our cross-sectional data suggest the presence of a biphasic radiological remodeling process in smokers: the presence of such nonlinearity must be accounted for in longitudinal computed tomographic studies. Baseline LM predicts the decline in lung function.
Details
- Title: Subtitle
- Lung Mass in Smokers
- Creators
- George R Washko - Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115Gregory L Kinney - Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, ColoradoJames C Ross - Surgical Planning Laboratory, Laboratory of Mathematics in Imaging, Department of Radiology, Brigham and Women's Hospital, Boston, MassachusettsRaúl San José Estépar - Surgical Planning Laboratory, Laboratory of Mathematics in Imaging, Department of Radiology, Brigham and Women's Hospital, Boston, MassachusettsMeiLan K Han - Department of Medicine, Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MichiganMark T Dransfield - Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AlabamaVictor Kim - Department of Medicine, Division of Pulmonary and Critical Care Medicine, Temple University School of Medicine, Philadelphia, PennsylvaniaHiroto Hatabu - Department of Radiology, Brigham and Women's Hospital, Boston, MassachusettsCarolyn E Come - Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115Russell P Bowler - Department of Medicine, Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, ColoradoEdwin K Silverman - Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsJames Crapo - Department of Medicine, Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, ColoradoDavid A Lynch - Department of Radiology, National Jewish Health, Denver, ColoradoJohn Hokanson - Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, ColoradoAlejandro A Diaz - Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115COPDGene Investigators
- Contributors
- Eric A Hoffman (Contributor) - University of Iowa, Radiology
- Resource Type
- Journal article
- Publication Details
- Academic radiology, Vol.24(4), pp.386-392
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.acra.2016.10.011
- PMID
- 27940230
- PMCID
- PMC5600161
- ISSN
- 1076-6332
- eISSN
- 1878-4046
- Grant note
- Brigham and Women's Hospital (http://dx.doi.org/10.13039/100005292) R01HL089897; R01HL089856; 1K25HL104085; R01 HL116473; R01 HL116473; R01 HL107246; K01HL118714-01 / National Institutes of Health (http://dx.doi.org/10.13039/100000002)
- Language
- English
- Date published
- 04/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Internal Medicine
- Record Identifier
- 9984051572102771
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