Lung Structure and Longitudinal Change in Cardiac Structure and Function: The MESA COPD Study

Emilia A Hermann; Yifei Sun; Eric Hoffman; Norrina Allen; Bharath Ambale-Venkatesh; David A Bluemke; John Jeffrey Carr; Steven M Kawut; Martin R Prince; Sanjiv J Shah; Benjamin M Smith; Karol E Watson; Joao A C Lima; R Graham Barr

doi:10.1183/13993003.00820-2024

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Lung Structure and Longitudinal Change in Cardiac Structure and Function: The MESA COPD Study

Journal article

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Lung Structure and Longitudinal Change in Cardiac Structure and Function: The MESA COPD Study

Emilia A Hermann, Yifei Sun, Eric Hoffman, Norrina Allen, Bharath Ambale-Venkatesh, David A Bluemke, John Jeffrey Carr, Steven M Kawut, Martin R Prince, Sanjiv J Shah, …

The European respiratory journal, Vol.64(6), 2400820

12/2024

DOI: 10.1183/13993003.00820-2024

PMCID: PMC12120402

PMID: 39362671

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Abstract

Lung structure and cardiac structure and function are associated cross-sectionally. The classic literature suggests relationships of airways disease to and emphysema to reduced cardiac output (CO) but longitudinal data are lacking. The Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease (COPD) Study was a multi-center longitudinal COPD case-control study of participants 50-79 years with ≥10 pack-years smoking without clinical cardiovascular disease. Segmental airway wall area (WA) and percent emphysema were measured on computed tomography. Right and left ventricle (RV, LV) parameters were assessed on magnetic resonance imaging (MRI) in exams six years apart. Longitudinal and period cross-sectional associations were evaluated with mixed models adjusted for demographics, body size, and smoking. The 187 participants with repeated MRI were 67±7 years old; 42% had COPD; 22% currently smoked; and the race/ethnicity distribution was 54% white, 30% Black, 14% Hispanic, and 3% Asian. Greater WA at enrollment was associated with longitudinal increase in RV mass (3.5 g per 10mm WA, 95% CI: 1.1, 5.9). Greater percent emphysema was associated with stably lower LV end diastolic volume (-7.8 mL per 5% emphysema, 95% CI: -10.3, -3.0) and CO (-0.2 L·min per 5% emphysema, 95% CI: -0.4, -0.1). Cardiac associations varied by lung structure over six years in this multi-ethnic study. Greater WA at enrollment was associated with longitudinal increases in RV mass; whereas greater percent emphysema was associated with stable decrements in LV filling and CO.

Details

Title: Subtitle: Lung Structure and Longitudinal Change in Cardiac Structure and Function: The MESA COPD Study
Creators: Emilia A Hermann - Columbia University Irving Medical Center
Yifei Sun - Columbia University Irving Medical Center
Eric Hoffman - University of Iowa
Norrina Allen - Northwestern University
Bharath Ambale-Venkatesh - Johns Hopkins Hospital
David A Bluemke - University of Wisconsin–Madison
John Jeffrey Carr - Vanderbilt University Medical Center
Steven M Kawut - University of Pennsylvania
Martin R Prince - Cornell University
Sanjiv J Shah - Northwestern University
Benjamin M Smith - Columbia University Irving Medical Center
Karol E Watson - University of California, Los Angeles
Joao A C Lima - Johns Hopkins Hospital
R Graham Barr - Columbia University Irving Medical Center
Resource Type: Journal article
Publication Details: The European respiratory journal, Vol.64(6), 2400820
DOI: 10.1183/13993003.00820-2024
PMID: 39362671
PMCID: PMC12120402
NLM abbreviation: Eur Respir J
ISSN: 0903-1936
eISSN: 1399-3003
Language: English
Electronic publication date: 10/03/2024
Date published: 12/2024
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984722574302771

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