Journal article
Lung Structure and Risk of Sleep Apnea in SPIROMICS
Chronic obstructive pulmonary diseases, Vol.11(1), pp.26-36
2024
DOI: 10.15326/jcopdf.2023.0411
PMCID: PMC10913931
PMID: 37931592
Abstract
RATIONALE SPIROMICS is a prospective cohort study that enrolled 2,981 participants with the goal of identifying new COPD subgroups and intermediate markers of disease progression. Individuals with COPD and sleep apnea (OSA) experience impaired quality of life and more frequent exacerbations. COPD severity also associates with CT-scan based emphysema and alterations in airway dimensions. OBJECTIVES To determine whether the combination of lung function and structure influences the risk of OSA among current and former smokers .METHODS Using two OSA risk scores, the Berlin Sleep Questionnaire (BSQ), and the DOISNORE50 (DIS), 1,767 current and former smokers were evaluated for association of lung structure and function with OSA risk .MEASUREMENTS AND MAIN RESULTS Study cohort mean age was 63 years, BMI 28 kg/m2, and FEV1 of 74.8% predicted. The majority were male (55%), white (77%), former smokers (59%), and had COPD (63%). A high-risk OSA score was reported in 36% and 61% using DIS and BSQ respectively. There was 9% increased odds of a high-risk DIS score (OR=1.09, 95%CI:1.03-1.14) and nominally increased odds of high-risk BSQ score for every 10% decrease in FEV1% predicted (OR=1.04, 95%CI:0.998-1.09). Lung function-OSA risk associations persisted after additionally adjusting for lung structure measurements (%emphysema, %air-trapping, PRM-fSAD, mean segmental wall area, tracheal %wall area, dysanapsis) for DIS (OR=1.12, 95%CI:1.03-1.22) and BSQ (OR=1.09, 95%CI:1.01-1.18).Conclusions Lower lung function independently associates with having high-risk for OSA in current and former smokers. Lung structural elements, especially dysanapsis, functional small airways disease, and tracheal %wall area strengthened the effects on OSA risk.
Details
- Title: Subtitle
- Lung Structure and Risk of Sleep Apnea in SPIROMICS
- Creators
- Abigail L KochTracie L ShingAndrew NamenDavid CouperBenjamin SmithR Graham BarrSurya BhattNirupama PutchaAaron BaughAmit K SahaMichelle ZiedlerAlejandro ComellasChristopher B CooperIgor BarjaktarevicRussell P BowlerMeilan K HanVictor KimRobert PaineRichard E KannerJerry A KrishnanFernando J MartinezPrescott G WoodruffNadia N HanselEric A HoffmanStephen P PetersVictor E Ortega
- Resource Type
- Journal article
- Publication Details
- Chronic obstructive pulmonary diseases, Vol.11(1), pp.26-36
- DOI
- 10.15326/jcopdf.2023.0411
- PMID
- 37931592
- PMCID
- PMC10913931
- ISSN
- 2372-952X
- eISSN
- 2372-952X
- Language
- English
- Electronic publication date
- 11/06/2023
- Date published
- 2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
- Record Identifier
- 9984511759902771
Metrics
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