Lung cancer histologic type in the surveillance, epidemiology, and end results registry versus independent review

R W Field; B J Smith; C E Platz; R A Robinson; J S Neuberger; C P Brus; C F Lynch

doi:10.1093/jnci/djh189

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Lung cancer histologic type in the surveillance, epidemiology, and end results registry versus independent review

Journal article

Open access

Peer reviewed

Lung cancer histologic type in the surveillance, epidemiology, and end results registry versus independent review

R W Field, B J Smith, C E Platz, R A Robinson, J S Neuberger, C P Brus and C F Lynch

JNCI : Journal of the National Cancer Institute, Vol.96(14), pp.1105-1107

07/21/2004

DOI: 10.1093/jnci/djh189

PMID: 15265973

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Abstract

Because few studies have assessed the accuracy of lung cancer histologic diagnoses reported by state cancer registries, we examined whether the Iowa Surveillance, Epidemiology, and End Results Cancer Registry (i.e., the Iowa Cancer Registry)-reported lung cancer histologic diagnoses were reliable. We investigated agreement between lung cancer histologic types reported for 413 patients with lung cancer by the Iowa Cancer Registry and those obtained through an independent review of diagnostic slides. Among lung cancer histologic types, small-cell carcinoma had the highest sensitivity (94.1%, 95% confidence interval [CI] = 85.6% to 98.4%), positive predictive value (94.1%, 95% CI = 85.6% to 98.4%), negative predictive value (98.8%, 95% CI = 96.9% to 99.7%), and highest percent exact agreement (98.0%, 95% CI = 96.6% to 99.4%). The lowest sensitivity (21.9%, 95% CI = 9.3% to 40.0%) and positive predictive value (23.3%, 95% CI = 9.9% to 42.3%) were noted for large-cell carcinoma, probably because other more specific features of adenocarcinoma or squamous carcinoma were absent. Adenocarcinoma had the lowest specificity (84.4%, 95% CI = 79.0% to 88.9%), negative predictive value (85.2%, 95% CI = 79.9% to 89.6%), and percent exact agreement (82.9%, 95% CI = 79.2% to 86.6%). Samples collected by cytologic examination (odds ratio [OR] = 2.4, 95% CI = 1.1 to 5.2) or biopsy examination (OR = 2.2, 95% CI = 1.1 to 4.2) were more likely to be misclassified than samples obtained via resection. Thus, the histologic type obtained by the Iowa Cancer Registry is reasonably reliable, but independent slide review is needed for precise histologic typing of lung cancer.

Predictive Value of Tests

Adenocarcinoma - pathology

United States

Adenocarcinoma - classification

Carcinoma, Large Cell - pathology

Carcinoma, Squamous Cell - pathology

Humans

Medical Audit

Lung Neoplasms - pathology

Case-Control Studies

Carcinoma, Small Cell - classification

Pathology - standards

Carcinoma, Non-Small-Cell Lung - classification

Lung Neoplasms - etiology

Sensitivity and Specificity

Carcinogens, Environmental - adverse effects

Odds Ratio

Carcinoma, Non-Small-Cell Lung - pathology

SEER Program

Radon - adverse effects

Lung Neoplasms - classification

Iowa

Air Pollutants, Radioactive - adverse effects

Carcinoma, Squamous Cell - classification

Carcinoma, Large Cell - classification

Carcinoma, Small Cell - pathology

Details

Title: Subtitle: Lung cancer histologic type in the surveillance, epidemiology, and end results registry versus independent review
Creators: R W Field - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, USA. bill-field@uiowa.edu
B J Smith
C E Platz
R A Robinson
J S Neuberger
C P Brus
C F Lynch
Resource Type: Journal article
Publication Details: JNCI : Journal of the National Cancer Institute, Vol.96(14), pp.1105-1107
DOI: 10.1093/jnci/djh189
PMID: 15265973
NLM abbreviation: J Natl Cancer Inst
ISSN: 0027-8874
eISSN: 1460-2105
Publisher: Oxford University Press; United States
Grant note: R01 CA85942 / NCI NIH HHS R01 ES05653 / NIEHS NIH HHS
Language: English
Date published: 07/21/2004
Academic Unit: Oral Pathology, Radiology and Medicine; Occupational and Environmental Health; Epidemiology; Pathology; Biostatistics; Holden Comprehensive Cancer Center
Record Identifier: 9983995120702771

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