Journal article
Lung cell exposure to secondary photochemical aerosols generated from OH oxidation of cyclic siloxanes
Chemosphere (Oxford), Vol.241, pp.125126-125126
02/2020
DOI: 10.1016/j.chemosphere.2019.125126
PMID: 31683444
Abstract
To study the fate of cyclic volatile methyl siloxanes (cVMS) undergoing photooxidation in the environment and to assess the acute toxicity of inhaled secondary aerosols from cVMS, we used an oxidative flow reactor (OFR) to produce aerosols from oxidation of decamethylcyclopentasiloxane (D5). The aerosols produced from this process were characterized for size, shape, and chemical composition. We found that the OFR produced aerosols composed of silicon and oxygen, arranged in chain agglomerates, with primary particles of approximately 31 nm in diameter. Lung cells were exposed to the secondary organosilicon aerosols at estimated doses of 54–116 ng/cm2 using a Vitrocell air-liquid interface system, and organic gases and ozone exposure was minimized through a series of denuders. Siloxane aerosols were not found to be highly toxic.
•Oxidative flow reactor used to study effects of secondary aerosols on lung cells.•Nanoparticulate aerosols generated from OH oxidation of D5, a cyclic siloxane.•Acute exposures to 54–116 ng/cm2 achieved using an air-liquid interface system.•Cytotoxic and proinflammatory effects marginal or absent at these doses.
Details
- Title: Subtitle
- Lung cell exposure to secondary photochemical aerosols generated from OH oxidation of cyclic siloxanes
- Creators
- Benjamin M King - Department of Chemical and Biochemical Engineering, The University of Iowa, 4133 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA, 52242, USANathan J Janechek - Department of Chemical and Biochemical Engineering, The University of Iowa, 4133 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA, 52242, USANathan Bryngelson - Department of Chemical and Biochemical Engineering, The University of Iowa, 4133 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA, 52242, USAAndrea Adamcakova-Dodd - Department of Occupational and Environmental Health, The University of Iowa, 145 N. Riverside Dr., Iowa City, IA, 52242, USATraci Lersch - RJ Lee Group, 350 Hochberg Road, Monroeville, PA, 15146, USAKristin Bunker - RJ Lee Group, 350 Hochberg Road, Monroeville, PA, 15146, USAGary Casuccio - RJ Lee Group, 350 Hochberg Road, Monroeville, PA, 15146, USAPeter S Thorne - Department of Occupational and Environmental Health, The University of Iowa, 145 N. Riverside Dr., Iowa City, IA, 52242, USACharles O Stanier - Department of Chemical and Biochemical Engineering, The University of Iowa, 4133 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA, 52242, USAJennifer Fiegel - Department of Chemical and Biochemical Engineering, The University of Iowa, 4133 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA, 52242, USA
- Resource Type
- Journal article
- Publication Details
- Chemosphere (Oxford), Vol.241, pp.125126-125126
- DOI
- 10.1016/j.chemosphere.2019.125126
- PMID
- 31683444
- NLM abbreviation
- Chemosphere
- ISSN
- 0045-6535
- eISSN
- 1879-1298
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100008893, name: University of Iowa, award: NIH P30 ES005605; DOI: 10.13039/100008893, name: University of Iowa; DOI: 10.13039/100011343, name: Holden Comprehensive Cancer Center; DOI: 10.13039/100008893, name: University of Iowa
- Language
- English
- Date published
- 02/2020
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health; Iowa Technology Institute; Stead Family Department of Pediatrics; Pharmaceutical Sciences and Experimental Therapeutics; Chemical and Biochemical Engineering
- Record Identifier
- 9984001090502771
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