Journal article
Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort
NPJ biofilms and microbiomes, Vol.7(1), 14
02/05/2021
DOI: 10.1038/s41522-021-00185-9
PMCID: PMC7865064
PMID: 33547327
Abstract
Chronic obstructive pulmonary disease (COPD) is heterogeneous in development, progression, and phenotypes. Little is known about the lung microbiome, sampled by bronchoscopy, in milder COPD and its relationships to clinical features that reflect disease heterogeneity (lung function, symptom burden, and functional impairment). Using bronchoalveolar lavage fluid collected from 181 never-smokers and ever-smokers with or without COPD (GOLD 0-2) enrolled in the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), we find that lung bacterial composition associates with several clinical features, in particular bronchodilator responsiveness, peak expiratory flow rate, and forced expiratory flow rate between 25 and 75% of FVC (FEF
). Measures of symptom burden (COPD Assessment Test) and functional impairment (six-minute walk distance) also associate with disparate lung microbiota composition. Drivers of these relationships include members of the Streptococcus, Prevotella, Veillonella, Staphylococcus, and Pseudomonas genera. Thus, lung microbiota differences may contribute to airway dysfunction and airway disease in milder COPD.
Details
- Title: Subtitle
- Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort
- Creators
- Kristopher Opron - University of Michigan–Ann ArborLesa A Begley - University of Michigan–Ann ArborJohn R Erb-Downward - University of Michigan–Ann ArborChristine Freeman - University of Michigan–Ann ArborSiddharth Madapoosi - University of Michigan–Ann ArborNeil E Alexis - University of North Carolina at Chapel HillIgor Barjaktarevic - Zhejiang UniversityR Graham Barr - Columbia University, New York, NY, USAEugene R Bleecker - University of ArizonaRussell P Bowler - National Jewish HealthStephanie A Christenson - University of California, San FranciscoAlejandro P Comellas - University of IowaChristopher B Cooper - Zhejiang UniversityDavid J Couper - University of North Carolina at Chapel HillClaire M Doerschuk - University of North Carolina at Chapel HillMark T Dransfield - University of Alabama at BirminghamMeiLan K Han - University of MichiganNadia N Hansel - University of BaltimoreAnnette T Hastie - Wake Forest UniversityEric A Hoffman - University of IowaRobert J Kaner - Cornell UniversityJerry Krishnan - University of Illinois ChicagoWanda K O'Neal - University of North Carolina at Chapel HillVictor E Ortega - Wake Forest UniversityRobert Paine III - University of UtahStephen P Peters - Wake Forest UniversityJ Michael Wells - University of Alabama at Birmingham, Birmingham, AL, USAPrescott G Woodruff - University of California, San FranciscoFernando J Martinez - Cornell UniversityJeffrey L Curtis - University of Michigan–Ann ArborGary B Huffnagle - University of Michigan–Ann ArborYvonne J Huang - University of Michigan–Ann Arbor
- Resource Type
- Journal article
- Publication Details
- NPJ biofilms and microbiomes, Vol.7(1), 14
- DOI
- 10.1038/s41522-021-00185-9
- PMID
- 33547327
- PMCID
- PMC7865064
- NLM abbreviation
- NPJ Biofilms Microbiomes
- ISSN
- 2055-5008
- eISSN
- 2055-5008
- Grant note
- HHSN268200900017C / NHLBI NIH HHS HHSN268200900019C / NHLBI NIH HHS R03 HL138310 / NHLBI NIH HHS HHSN268200900020C / NHLBI NIH HHS U24 HL141762 / NHLBI NIH HHS U01 HL137880 / NHLBI NIH HHS R01 HL121774 / NHLBI NIH HHS HHSN268200900015C / NHLBI NIH HHS HHSN268200900013C / NHLBI NIH HHS K24 HL137013 / NHLBI NIH HHS R01 AI129958 / NIAID NIH HHS HHSN268200900016C / NHLBI NIH HHS HHSN268200900018C / NHLBI NIH HHS HHSN268200900014C / NHLBI NIH HHS K23 HL123778 / NHLBI NIH HHS P30 DK054759 / NIDDK NIH HHS
- Language
- English
- Date published
- 02/05/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
- Record Identifier
- 9984318685902771
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