Journal article
Lung transplantation from donation after cardiocirculatory death: a systematic review and meta-analysis
The Journal of heart and lung transplantation, Vol.34(5), pp.675-684
05/2015
DOI: 10.1016/j.healun.2014.11.009
PMID: 25638297
Abstract
Lung transplantation (LTx) can extend life expectancy and enhance the quality of life for select patients with end-stage lung disease. In the setting of donor lung shortage and waiting list mortality, the interest in donation after cardiocirculatory death (DCD) is increasing. We performed a systematic review and meta-analysis to compare outcomes between DCD and conventional donation after brain death (DBD).
PubMed, CINAHL, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, and ClinicalTrials.gov were searched. We identified original research studies with 1-year post-transplant survival data involving >5 DCD transplants. We performed meta-analyses examining 1-year survival, primary graft dysfunction, and acute rejection after LTx.
We identified 519 citations; 11 observational cohort studies met our inclusion criteria for systematic review, and 6 met our inclusion criteria for meta-analysis. There were no differences found in 1-year mortality after LTx between DCD and DBD cohorts in individual studies or in the meta-analysis (DCD [n = 271] vs DBD [n = 2,369], relative risk [RR] 0.88, 95% confidence interval [CI] 0.59–1.31, p = 0.52, I2 = 0%). There was also no difference between DCD and DBD in a pooled analysis of 5 studies reporting on primary graft dysfunction (RR 1.09, 95% CI 0.68–1.73, p = 0.7, I2 = 0%) and 4 studies reporting on acute rejection (RR 0.72, 95% CI 0.49–1.05, p = 0.09, I2 = 0%).
Survival after LTx from DCD is comparable to survival after LTx from DBD in observational cohort studies. DCD appears to be a safe and effective method to expand the donor pool.
Details
- Title: Subtitle
- Lung transplantation from donation after cardiocirculatory death: a systematic review and meta-analysis
- Creators
- Dustin Krutsinger - Department of Medicine, University of Iowa, Iowa City, IowaMichael Eberlein - Department of Medicine, University of Iowa, Iowa City, IowaRobert M Reed - Division of Pulmonary and Critical Care Medicine, University of Maryland, Baltimore, MarylandAmy Blevins - Hardin Library for the Health Sciences, University of Iowa, Iowa City, IowaVarun Puri - Department of Surgery, Washington University, St. Louis, MissouriNilto C De Oliveira - Division of Cardiothoracic Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WisconsinBartlomiej Zych - Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton & Harefield NHS Foundation Trust, Harefield Hospital, London, United KingdomServet Bolukbas - Department of Thoracic Surgery, Dr. Korst Schmidt Klinik, Wiesbaden, GermanyDirk Van Raemdonck - Department of Thoracic Surgery and Lung Transplant Unit, University Hospitals Leuven, Leuven, BelgiumGregory I Snell - Lung Transplant Service, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Australia
- Resource Type
- Journal article
- Publication Details
- The Journal of heart and lung transplantation, Vol.34(5), pp.675-684
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.healun.2014.11.009
- PMID
- 25638297
- ISSN
- 1053-2498
- eISSN
- 1557-3117
- Language
- English
- Date published
- 05/2015
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984094353302771
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