Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Sasha Bernatsky; Héctor A Velásquez García; John J Spinelli; Patrick Gaffney; Karin E Smedby; Rosalind Ramsey-Goldman; Sophia S Wang; Hans-Olov Adami; Demetrius Albanes; Emanuele Angelucci; Stephen M Ansell; Yan W Asmann; Nikolaus Becker; Yolanda Benavente; Sonja I Berndt; Kimberly A Bertrand; Brenda M Birmann; Heiner Boeing; Paolo Boffetta; Paige M Bracci; Paul Brennan; Angela R Brooks-Wilson; James R Cerhan; Stephen J Chanock; Jacqueline Clavel; Lucia Conde; Karen H Cotenbader; David G Cox; Wendy Cozen; Simon Crouch; Anneclaire J De Roos; Silvia de Sanjose; Simonetta Di Lollo; W Ryan Diver; Ahmet Dogan; Lenka Foretova; Hervé Ghesquières; Graham G Giles; Bengt Glimelius; Thomas M Habermann; Corinne Haioun; Patricia Hartge; Henrik Hjalgrim; Theodore R Holford; Elizabeth A Holly; Rebecca D Jackson; Rudolph Kaaks; Eleanor Kane; Rachel S Kelly; Robert J Klein; Peter Kraft; Anne Kricker; Qing Lan; Charles Lawrence; Mark Liebow; Tracy Lightfoot; Brian K Link; Marc Maynadie; James McKay; Mads Melbye; Thierry J Molina; Alain Monnereau; Lindsay M Morton; Alexandra Nieters; Kari E North; Anne J Novak; Kenneth Offit; Mark P Purdue; Marco Rais; Jacques Riby; Eve Roman; Nathaniel Rothman; Gilles Salles; Gianluca Severi; Richard K Severson; Christine F Skibola; Susan L Slager; Alex Smith; Martyn T Smith; Melissa C Southey; Anthony Staines; Lauren R Teras; Carrie A Thompson; Hervé Tilly; Lesley F Tinker; Anne Tjonneland; Jenny Turner; Claire M Vajdic; Roel C H Vermeulen; Joseph Vijai; Paolo Vineis; Jarmo Virtamo; Zhaoming Wang; Stephanie Weinstein; Thomas E Witzig; Andrew Zelenetz; Anne Zeleniuch-Jacquotte; Yawei Zhang; Tongzhang Zheng; Mariagrazia Zucca; Ann E Clarke

doi:10.1136/lupus-2016-000187

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Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

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Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Sasha Bernatsky, Héctor A Velásquez García, John J Spinelli, Patrick Gaffney, Karin E Smedby, Rosalind Ramsey-Goldman, Sophia S Wang, Hans-Olov Adami, Demetrius Albanes, Emanuele Angelucci, …

Lupus science & medicine, Vol.4(1), pp.e000187-e000187

10/2017

DOI: 10.1136/lupus-2016-000187

PMCID: PMC5715504

PMID: 29214033

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Abstract

ObjectiveDeterminants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.MethodsGWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.ResultsAmong the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.ConclusionsThese data suggest several plausible genetic links between DLBCL and SLE.

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Title: Subtitle: Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
Creators: Sasha Bernatsky - Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, Canada
Héctor A Velásquez García - BC Cancer Research Centre and School of Population and Public Health, University of British Columbia, Vancouver, Canada
John J Spinelli - BC Cancer Research Centre and School of Population and Public Health, University of British Columbia, Vancouver, Canada
Patrick Gaffney - Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
Karin E Smedby - Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, and Hematology Center, Karolinska University Hospital, Stockholm, Sweden
Rosalind Ramsey-Goldman - Feinberg School of Medicine, Northwestern University, Chicago, USA
Sophia S Wang - Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, Duarte, USA
Hans-Olov Adami - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA
Demetrius Albanes - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA
Emanuele Angelucci - Hematology Unit, Ospedale Oncologico di Riferimento Regionale ‘A. Businco’, Cagliari, Italy
Stephen M Ansell - Department of Medicine, Mayo Clinic, Rochester, USA
Yan W Asmann - Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Jacksonville, USA
Nikolaus Becker - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Yolanda Benavente - Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
Sonja I Berndt - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA
Kimberly A Bertrand - Slone Epidemiology Center, Boston University, Boston, USA
Brenda M Birmann - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
Heiner Boeing - Department of Epidemiology, German Institute for Human Nutrition, Potsdam, Germany
Paolo Boffetta - The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA
Paige M Bracci - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, USA
Paul Brennan - International Agency for Research on Cancer (IARC), Lyon, France
Angela R Brooks-Wilson - Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada
James R Cerhan - Department of Health Sciences Research, Mayo Clinic, Rochester, USA
Stephen J Chanock - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA
Jacqueline Clavel - Epidemiology of childhood and adolescent cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France
Lucia Conde - Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, USA
Karen H Cotenbader - Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, USA
David G Cox - INSERM U, Cancer Research Center of Lyon, Centre Léon Bérard, Lyon, France
Wendy Cozen - Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, USA
Simon Crouch - Department of Health Sciences, University of York, York, UK
Anneclaire J De Roos - Department of Environmental and Occupational Health, Dornsife School of Public Health at Drexel University, Philadelphia, USA
Silvia de Sanjose - CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Simonetta Di Lollo - Department of Surgery and Translational Medicine, Section of Anatomo-Pathology, University of Florence, Florence, Italy
W Ryan Diver - Epidemiology Research Program, American Cancer Society, Atlanta, USA
Ahmet Dogan - Departments of Laboratory Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, USA
Lenka Foretova - Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno, Czech Republic
Hervé Ghesquières - Department of Hematology, Centre Léon Bérard, Lyon, France
Graham G Giles - Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia
Bengt Glimelius - Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Thomas M Habermann - Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, USA
Corinne Haioun - Lymphoid Malignancies Unit, Henri Mondor Hospital and University Paris Est, Créteil, France
Patricia Hartge - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA
Henrik Hjalgrim - Division of Health Surveillance and Research, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
Theodore R Holford - Department of Biostatistics, Yale School of Public Health, New Haven, USA
Elizabeth A Holly - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, USA
Rebecca D Jackson - Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, USA
Rudolph Kaaks - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Eleanor Kane - Department of Health Sciences, University of York, York, UK
Rachel S Kelly - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
Robert J Klein - Icahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA
Peter Kraft - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA
Anne Kricker - Sydney School of Public Health, The University of Sydney, Sydney, Australia
Qing Lan - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA
Charles Lawrence - Westat Inc, Rockville, USA
Mark Liebow - Department of Medicine, Mayo Clinic, Rochester, USA
Tracy Lightfoot - Department of Health Sciences, University of York, York, UK
Brian K Link - Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, USA
Marc Maynadie - Registre des Hémopathies Malignes de Côte d'Or, EA , Univ. Bourgogne Franche-Comté and Dijon University Hospital, Dijon, France
James McKay - International Agency for Research on Cancer (IARC), Lyon, France
Mads Melbye - Division of Health Surveillance and Research, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
Thierry J Molina - Department of Pathology, AP-HP, Necker Enfants malades, Université Paris Descartes, Sorbonne Paris Cité, France
Alain Monnereau - Epidemiology of childhood and adolescent cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France
Lindsay M Morton - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA
Alexandra Nieters - Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany
Kari E North - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, USA
Anne J Novak - Department of Medicine, Mayo Clinic, Rochester, USA
Kenneth Offit - Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA
Mark P Purdue - Ontario Health Study, Toronto, Canada
Marco Rais - Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Italy
Jacques Riby - Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, USA
Eve Roman - Department of Health Sciences, University of York, York, UK
Nathaniel Rothman - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA
Gilles Salles - Department of Hematology, Hospices Civils de Lyon, Pierre benite Cedex, France
Gianluca Severi - Human Genetics Foundation, Turin, Italy
Richard K Severson - Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, USA
Christine F Skibola - Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, USA
Susan L Slager - Department of Health Sciences Research, Mayo Clinic, Rochester, USA
Alex Smith - Department of Health Sciences, University of York, York, UK
Martyn T Smith - Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, USA
Melissa C Southey - Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Australia
Anthony Staines - School of Nursing and Human Sciences, Dublin City University, Dublin, Ireland
Lauren R Teras - Epidemiology Research Program, American Cancer Society, Atlanta, USA
Carrie A Thompson - Department of Medicine, Mayo Clinic, Rochester, USA
Hervé Tilly - Centre Heni Becquerel, Université de Rouen, Rouen, France
Lesley F Tinker - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA
Anne Tjonneland - Danish Cancer Society Research Center, Copenhagen, Denmark
Jenny Turner - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
Claire M Vajdic - Centre for Big Data Research in Health, University of New South Wales, Sydney, Australia
Roel C H Vermeulen - Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
Joseph Vijai - Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA
Paolo Vineis - MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
Jarmo Virtamo - Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
Zhaoming Wang - Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
Stephanie Weinstein - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA
Thomas E Witzig - Department of Medicine, Mayo Clinic, Rochester, USA
Andrew Zelenetz - Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA
Anne Zeleniuch-Jacquotte - Department of Population Health, New York University School of Medicine, New York, USA
Yawei Zhang - Department of Environmental Health Sciences, Yale School of Public Health, New Haven, USA
Tongzhang Zheng - Department of Epidemiology, Brown School of Public Health, Providence, USA
Mariagrazia Zucca - Department of Biomedical Science, University of Cagliari, Monserrato, Italy
Ann E Clarke - Division of Rheumatology, University of Calgary, Calgary, Canada
Resource Type: Journal article
Publication Details: Lupus science & medicine, Vol.4(1), pp.e000187-e000187
DOI: 10.1136/lupus-2016-000187
PMID: 29214033
PMCID: PMC5715504
NLM abbreviation: Lupus Sci Med
ISSN: 2053-8790
eISSN: 2053-8790
Grant note: DOI: 10.13039/100000009, name: Foundation for the National Institutes of Health, award: NO1-CO-12400
Language: English
Date published: 10/2017
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
Record Identifier: 9984071799902771

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