Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas: A Consensus Opinion from the Children's Oncology Group, European paediatric Soft tissue sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe

Sheila Terwisscha van Scheltinga; Reineke A Schoot; Jonathan C Routh; Guido Seitz; Simon C Kao; Bart de Keizer; Barry Shulkin; Roelof van Ewijk; Beth McCarville; Dana Casey; Wendy Allen-Rhoades; Federico Mercolini; Hans Merks; Daniel Orbach; Tejas Kapadia; David O Walterhouse; Raquel Davila Fajardo; Laura Hiemcke-Jiwa; Christiane Franzius; Federica De Corti; Vivian Tang; Jonathan Metts; Saphna Oberoi; Christian Vokuhl; Roshni Dasgupta; Suzi Birz; David Rodeberg

doi:10.1002/pbc.31538

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Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas: A Consensus Opinion from the Children's Oncology Group, European paediatric Soft tissue sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe

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Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas: A Consensus Opinion from the Children's Oncology Group, European paediatric Soft tissue sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe

Sheila Terwisscha van Scheltinga, Reineke A Schoot, Jonathan C Routh, Guido Seitz, Simon C Kao, Bart de Keizer, Barry Shulkin, Roelof van Ewijk, Beth McCarville, Dana Casey, …

Pediatric blood & cancer, Vol.72(4), e31538

04/2025

DOI: 10.1002/pbc.31538

PMCID: PMC12083081

PMID: 39844722

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Abstract

Accurate staging of nodal involvement in pediatric sarcoma patients is important to determine correct systemic and local therapy, with the goal to reduce subsequent recurrences. However, differences in lymph node staging strategies, definitions, and treatment protocols between the Children's Oncology Group (COG), European paediatric Soft tissue sarcoma Study Group (EpSSG), and the Cooperative Weichteilsarkom Studiengruppe (CWS) complicate comparisons. In this article, we aim to establish internationally recognized recommendations for lymph node assessment and treatment of children and adolescents diagnosed with rhabdomyosarcoma (RMS) and non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) according to the Consensus Conference Standard Operating Procedure methodology.

including soft tissue

pediatric oncology

non‐rhabdoid

rhabdomyosarcoma

sarcomas

Details

Title: Subtitle: Lymph Node Staging and Treatment in Pediatric Patients With Soft Tissue Sarcomas: A Consensus Opinion from the Children's Oncology Group, European paediatric Soft tissue sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe
Creators: Sheila Terwisscha van Scheltinga - Princess Máxima Center
Reineke A Schoot - Princess Máxima Center
Jonathan C Routh - Duke University
Guido Seitz - Universitätsklinikum Gießen und Marburg
Simon C Kao - University of Iowa
Bart de Keizer - Wilhelmina Children's Hospital
Barry Shulkin - St. Jude Children's Research Hospital
Roelof van Ewijk - Princess Máxima Center
Beth McCarville - St. Jude Children's Research Hospital
Dana Casey - University of North Carolina at Chapel Hill
Wendy Allen-Rhoades - Mayo Clinic
Federico Mercolini - Azienda USL di Bologna
Hans Merks - University Medical Center Utrecht
Daniel Orbach - Institut Curie
Tejas Kapadia - Royal Manchester Children's Hospital
David O Walterhouse - Lurie Children's Hospital
Raquel Davila Fajardo - University Medical Center Utrecht
Laura Hiemcke-Jiwa - University Medical Center Utrecht
Christiane Franzius - Klinik und Poliklinik für Nuklearmedizin
Federica De Corti - University of Padua
Vivian Tang - Royal Manchester Children's Hospital
Jonathan Metts - Moffitt Cancer Center
Saphna Oberoi - CancerCare Manitoba
Christian Vokuhl - University Hospital Bonn
Roshni Dasgupta - Cincinnati Children's Hospital Medical Center
Suzi Birz - University of Chicago
David Rodeberg - University of Kentucky
Resource Type: Journal article
Publication Details: Pediatric blood & cancer, Vol.72(4), e31538
DOI: 10.1002/pbc.31538
PMID: 39844722
PMCID: PMC12083081
NLM abbreviation: Pediatr Blood Cancer
ISSN: 1545-5017
eISSN: 1545-5017
Publisher: WILEY
Grant note: International Soft Tissue Sarcoma ConsortiumCancer Research FoundationChildren's Research FoundationComer Development BoardRally Foundation for Childhood Cancer Research, Seattle Children's Foundation from Kat's Crew Guild through the Sarcoma Research FundSt. Baldrick's FoundationAndrew McDonough B+ FoundationMaddie's Promise, Summer's Way FoundationSeattle Children's FoundationMMT Malignant Mesenchymal Tumour CommitteeSTSC AIEOP Italian Soft Tissue Sarcoma Committee
The International Soft Tissue Sarcoma Consortium and the Pediatric Cancer Data Commons are supported in part by Cancer Research Foundation, Children's Research Foundation, Comer Development Board, KickCancer, King Baudouin Foundation, Rally Foundation for Childhood Cancer Research, Seattle Children's Foundation from Kat's Crew Guild through the Sarcoma Research Fund, St. Baldrick's Foundation, The Andrew McDonough B+ Foundation, Maddie's Promise, Summer's Way Foundation, Friends of T.J. Foundation, Sebastian Strong, and the Sarah Jane Adicoff Endowment for Research in Rhabdomyosarcoma through the Seattle Children's Foundation. This work is made possible through the efforts of Children's Oncology Group, Cooperative Weichteilsarkom Studiengruppe der GPOH (CWS), the European paediatric Soft tissue sarcoma Study Group, MMT Malignant Mesenchymal Tumour Committee, and STSC AIEOP Italian Soft Tissue Sarcoma Committee.
Language: English
Electronic publication date: 01/23/2025
Date published: 04/2025
Academic Unit: Radiology; Stead Family Department of Pediatrics
Record Identifier: 9984775264802771

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