Journal article
Lymph nodes and Peyer's patches of IL-6 transgenic BALB/c mice harbor T(12;15) translocated plasma cells that contain illegitimate exchanges between the immunoglobulin heavy-chain μ locus and c-myc
Leukemia, Vol.14(6), pp.1127-1135
2000
DOI: 10.1038/sj.leu.2401767
PMID: 10865979
Abstract
Hyperplastic plasmacytotic lymph nodes and Peyer's patches of 12 of 25 (48%) BALB/c mice that carried a human IL-6 transgene under the transcriptional control of the histocompatibility H-2LD promoter (BALB/c.IL-6 mice) were found to harbor 15 cell clones that contained in their T(12;15) translocation breakpoint regions illegitimate genetic recombinations between the upstream flank of the immunoglobulin heavy-chain Cμ locus (5′-Cμ) and c-myc(5′-Cμ/c-myc+ clones). Similar 5′-Cμ/c-myc+ clones were also detected in pristane-induced peritoneal granulomata (a significant source of IL-6 in situ) of three of 13 (13%) conventional BALB/c mice, but not in lymphoid tissues of pristane-treated BALB/c mice, nor in any tissue of untreated BALB/c mice. These findings provided strong evidence that IL-6 may be able to promote the growth and/or survival of clones that contained rearrangements between 5′-Cμ and c-myc. Taken in conjunction with our previous observation that 5′-Cμ/c-myc+ clones are the precursors for pristane-induced BALB/c plasmacytomas, the findings further suggested that IL-6 may play a pivotal role in the early stage of plasmacytoma development, by promoting tumor precursor cells. The BALB/c.IL-6 model of plasmacytomagenesis may be superior to the conventional BALA/c model because the putative plasmacytoma precursors appear to be more prevalent and in their development independent of treating the mice with inflammation-inducing plasmacytomagenic agents, such as pristane or silicone polymers.
Details
- Title: Subtitle
- Lymph nodes and Peyer's patches of IL-6 transgenic BALB/c mice harbor T(12;15) translocated plasma cells that contain illegitimate exchanges between the immunoglobulin heavy-chain μ locus and c-myc
- Creators
- A. L KOVALCHUK - Laboratory of Genetics, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, United StatesT KISHIMOTO - Institute for Molecular and Cellular Biology, Osaka University Medical School, Osaka, JapanS JANZ - Laboratory of Genetics, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States
- Resource Type
- Journal article
- Publication Details
- Leukemia, Vol.14(6), pp.1127-1135
- DOI
- 10.1038/sj.leu.2401767
- PMID
- 10865979
- NLM abbreviation
- Leukemia
- ISSN
- 0887-6924
- eISSN
- 1476-5551
- Publisher
- Nature Publishing
- Language
- English
- Date published
- 2000
- Academic Unit
- Pathology
- Record Identifier
- 9984083867402771
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