Journal article
Lymphomatoid granulomatosis presenting with cutaneous involvement: a case report and review of the literature
Journal of cutaneous pathology, Vol.42(3), pp.188-193
03/2015
DOI: 10.1111/cup.12402
PMID: 25355540
Abstract
Lymphomatoid granulomatosis (LG) is a rare Epstein–Barr virus (EBV)‐associated B‐cell lymphoproliferative disorder presenting in middle adulthood that nearly always affects the lungs and shows cutaneous involvement in up to 50% of cases. Skin lesions are present at the time of diagnosis in roughly one‐third of patients and may precede the development of lung lesions in as many as 10–15%. Recognition by both the dermatologist and dermatopathologist is therefore crucial for early and accurate diagnosis. While skin involvement is grossly and microscopically diverse, the disease most commonly presents as erythematous subcutaneous and dermal nodules showing the classic histopathologic triad of transmural lymphocytic angiitis, atypical B‐lymphocytes in a polymorphous T‐cell background, and necrotic foci within lymphoid aggregates. We present a case of lymphomatoid granulomatosis initially presenting with cutaneous lesions, with an accompanying review of the literature.
Details
- Title: Subtitle
- Lymphomatoid granulomatosis presenting with cutaneous involvement: a case report and review of the literature
- Creators
- Carolyn D Rysgaard - Carver College of Medicine, University of IowaMary Seabury Stone - Carver College of Medicine, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of cutaneous pathology, Vol.42(3), pp.188-193
- Publisher
- Blackwell Publishing Ltd; Oxford, UK
- DOI
- 10.1111/cup.12402
- PMID
- 25355540
- ISSN
- 0303-6987
- eISSN
- 1600-0560
- Number of pages
- 6
- Language
- English
- Date published
- 03/2015
- Academic Unit
- Dermatology; Pathology
- Record Identifier
- 9984025478702771
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