Journal article
Lymphopenia and clinical outcomes in patients with residual nodal disease after neoadjuvant chemotherapy for breast cancer
Cancer causes & control, Vol.31(11), pp.1021-1026
11/01/2020
DOI: 10.1007/s10552-020-01337-6
PMID: 32888164
Abstract
Background Patients with residual nodal disease after neoadjuvant chemotherapy for breast cancer have a poor prognosis. We wanted to evaluate whether lymphopenia after treatment for breast cancer impacted clinical outcomes. Materials and methods We assessed 99 patients with node-positive disease after neoadjuvant chemotherapy. Absolute lymphocyte count was recorded 1 year after radiation. Dates of local, regional, and distant failure were recorded. Time to event outcomes were evaluated using Kaplan-Meier analysis. Multivariable analysis determined factors predictive for overall survival. Results Median follow-up was 44 months (range 3-150). Median age was 48 years (range 23-79). Twenty-six patients (26%) had lymphopenia 1 year after RT. Patients with lymphopenia had a greater incidence of regional (p = 0.03) and distant failure (p = 0.009) compared to those with normal lymphocyte counts and had a 6.05 greater risk of death (p = 0.0002). Conclusions In patients with residual nodal disease after neoadjuvant chemotherapy, lymphopenia after breast cancer treatment was associated with overall survival. The relationship between lymphopenia and breast cancer outcomes warrants further investigation.
Details
- Title: Subtitle
- Lymphopenia and clinical outcomes in patients with residual nodal disease after neoadjuvant chemotherapy for breast cancer
- Creators
- Paulina M. Gutkin - Stanford UniversityMargaret M. Kozak - Stanford UniversityRie von Eyben - Stanford UniversityKathleen C. Horst - Stanford University
- Resource Type
- Journal article
- Publication Details
- Cancer causes & control, Vol.31(11), pp.1021-1026
- Publisher
- Springer Nature
- DOI
- 10.1007/s10552-020-01337-6
- PMID
- 32888164
- ISSN
- 0957-5243
- eISSN
- 1573-7225
- Number of pages
- 6
- Language
- English
- Date published
- 11/01/2020
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984312976102771
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