Journal article
Lymphotoxin Is Required for Maintaining Physiological Levels of Serum IgE That Minimizes Th1-mediated Airway Inflammation
The Journal of experimental medicine, Vol.198(11), pp.1643-1652
12/01/2003
DOI: 10.1084/jem.20021784
PMCID: PMC2194142
PMID: 14638845
Abstract
Although elevated levels of IgE in asthmatic patients are strongly associated with lung infiltration by activated T helper (Th) 2 cells, the physiological role of immunoglobulin E (IgE) in the airway remains largely undefined. Lymphotoxin-deficient α (LTα−/−) mice exhibit increased airway inflammation, paradoxically accompanied by diminished levels of IgE and reduced airway hyperresponsiveness in response to both environmental and induced antigen challenge. The severe lung inflammation in LTα−/− mice is Th1 in nature and can be alleviated by IgE reconstitution. Conversely, depletion of IgE in wild-type mice recapitulates the lung pathologies of LTα−/− mice. Therefore, this work has revealed that lymphotoxin is essential for IgE production, and a physiological role of IgE in the airway may consist of maintaining the balance of Th1 and Th2 responses to prevent aberrant inflammation.
Details
- Title: Subtitle
- Lymphotoxin Is Required for Maintaining Physiological Levels of Serum IgE That Minimizes Th1-mediated Airway Inflammation
- Creators
- Hyung-Sik Kang - Department of Pathology, The University of Chicago, Chicago, IL 60637Sarah E Blink - Department of Pathology, The University of Chicago, Chicago, IL 60637Robert K Chin - Department of Pathology, The University of Chicago, Chicago, IL 60637Youjin Lee - Department of Pathology, The University of Chicago, Chicago, IL 60637Oliver Kim - Department of Pathology, The University of Chicago, Chicago, IL 60637Joel Weinstock - Department of Medicine, University of Iowa, Iowa City, IA 52242Thomas Waldschmidt - Department of Anatomy, University of Iowa, Iowa City, IA 52242Daniel Conrad - Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298Bohao Chen - Department of Medicine, The University of Chicago, Chicago, IL 60637Julian Solway - Department of Medicine, The University of Chicago, Chicago, IL 60637Anne I Sperling - Department of Medicine, The University of Chicago, Chicago, IL 60637Yang-Xin Fu - Department of Pathology, The University of Chicago, Chicago, IL 60637
- Resource Type
- Journal article
- Publication Details
- The Journal of experimental medicine, Vol.198(11), pp.1643-1652
- DOI
- 10.1084/jem.20021784
- PMID
- 14638845
- PMCID
- PMC2194142
- ISSN
- 0022-1007
- eISSN
- 1540-9538
- Language
- English
- Date published
- 12/01/2003
- Academic Unit
- Pathology
- Record Identifier
- 9984046928902771
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