Journal article
Lysosomal physiology and pancreatic lysosomal stress in diabetes mellitus
eGastroenterology, Vol.2(3), e100096
08/2024
DOI: 10.1136/egastro-2024-100096
PMCID: PMC11542681
PMID: 39512752
Abstract
Endocrine and exocrine functions of the pancreas control nutritional absorption, utilisation and systemic metabolic homeostasis. Under basal conditions, the lysosome is pivotal in regulating intracellular organelles and metabolite turnover. In response to acute or chronic stress, the lysosome senses metabolic flux and inflammatory challenges, thereby initiating the adaptive programme to re-establish cellular homeostasis. A growing body of evidence has demonstrated the pathophysiological relevance of the lysosomal stress response in metabolic diseases in diverse sets of tissues/organs, such as the liver and the heart. In this review, we discuss the pathological relevance of pancreatic lysosome stress in diabetes mellitus. We begin by summarising lysosomal biology, followed by exploring the immune and metabolic functions of lysosomes and finally discussing the interplay between lysosomal stress and the pathogenesis of pancreatic diseases. Ultimately, our review aims to enhance our understanding of lysosomal stress in disease pathogenesis, which could potentially lead to the discovery of innovative treatment methods for these conditions.
Details
- Title: Subtitle
- Lysosomal physiology and pancreatic lysosomal stress in diabetes mellitus
- Creators
- Meihua HaoSara C SebagQingwen QianLing Yang
- Resource Type
- Journal article
- Publication Details
- eGastroenterology, Vol.2(3), e100096
- DOI
- 10.1136/egastro-2024-100096
- PMID
- 39512752
- PMCID
- PMC11542681
- NLM abbreviation
- eGastroenterology
- ISSN
- 2766-0125
- eISSN
- 2976-7296
- Language
- English
- Date published
- 08/2024
- Academic Unit
- Molecular Physiology and Biophysics; Anatomy and Cell Biology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984701660302771
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