MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN

Pavithra Vivekanand; Tina L Tootle; Ilaria Rebay

doi:10.1016/j.mod.2004.07.009

Back

MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN

Journal article

Open access

Peer reviewed

MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN

Pavithra Vivekanand, Tina L Tootle and Ilaria Rebay

Mechanisms of development, Vol.121(12), pp.1469-1479

2004

DOI: 10.1016/j.mod.2004.07.009

PMID: 15511639

Files and links (1)

url

https://doi.org/10.1016/j.mod.2004.07.009View

Published (Version of record) Open Access

Abstract

Ets transcription factors play crucial roles in regulating diverse cellular processes including cell proliferation, differentiation and survival. Coordinated regulation of the Drosophila Ets transcription factors YAN and POINTED is required for eliciting appropriate responses to Receptor Tyrosine Kinase (RTK) signaling. YAN, a transcriptional repressor, and POINTED, a transcriptional activator, compete for regulatory regions of common target genes, with the ultimate outcome likely influenced by context-specific interactions with binding partners such as MAE. Previous work in cultured cells has led us to propose that MAE attenuates the transcriptional activity of both YAN and POINTED, although its effects on POINTED remain controversial. Here we describe a new layer of complexity to this regulatory hierarchy whereby mae expression is itself directly regulated by the opposing action of YAN and POINTED. In addition, we report that MAE can antagonize POINTED function during eye development; a finding that suggests MAE operates as a dual positive and negative regulator of RTK-mediated signaling in vivo. Together our results lead us to propose that a combination of protein-protein and transcriptional interactions between MAE, YAN and POINTED establishes a complex regulatory circuit that ensures that both down-regulation and activation of the RTK pathway occur appropriately according to specific developmental context.

Signal transduction

Drosophila

Receptor tyrosine kinase

Ets transcription factor

Eye development

S2 cultured cells

Pointed domain

Epidermal growth factor receptor

Details

Title: Subtitle: MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN
Creators: Pavithra Vivekanand - Whitehead Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
Tina L Tootle - Whitehead Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
Ilaria Rebay - Whitehead Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
Resource Type: Journal article
Publication Details: Mechanisms of development, Vol.121(12), pp.1469-1479
DOI: 10.1016/j.mod.2004.07.009
PMID: 15511639
NLM abbreviation: Mech Dev
ISSN: 0925-4773
eISSN: 1872-6356
Publisher: Elsevier Ireland Ltd
Language: English
Date published: 2004
Academic Unit: Anatomy and Cell Biology
Record Identifier: 9984025422502771

Metrics

17 Record Views

24 Times Cited - Web of Science