Journal article
MCH Neuron Activity Is Sufficient for Reward and Reinforces Feeding
Neuroendocrinology, Vol.110(3-4), pp.258-270
2020
DOI: 10.1159/000501234
PMID: 31154452
Abstract
Melanin-concentrating hormone (MCH)-expressing neurons have been implicated in regulation of energy homeostasis and reward, yet the role of their electrical activity in short-term appetite and reward modulation has not been fully understood.
We investigated short-term behavioral and physiological effects of MCH neuron activity manipulations.
We used optogenetic and chemogenetic approaches in Pmch-cre transgenic mice to acutely stimulate/inhibit MCH neuronal activity while probing feeding, locomotor activity, anxiety-like behaviors, glucose homeostasis, and reward.
MCH neuron activity is neither required nor sufficient for short-term appetite unless stimulation is temporally paired with consumption. MCH neuronal activation does not affect short-term locomotor activity, but inhibition improves glucose tolerance and is mildly anxiolytic. Finally, using two different operant tasks, we showed that activation of MCH neurons alone is sufficient to induce reward.
Our results confirm diverse behavioral/physiological functions of MCH neurons and suggest a direct role in reward function.
Details
- Title: Subtitle
- MCH Neuron Activity Is Sufficient for Reward and Reinforces Feeding
- Creators
- Pelin Dilsiz - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyIltan Aklan - Department of Pharmacology, Iowa Neuroscience Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USANilufer Sayar Atasoy - Department of Pharmacology, Iowa Neuroscience Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USAYavuz Yavuz - Department of Physiology, School of Medicine, Yeditepe University, Istanbul, TurkeyGizem Filiz - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyFulya Koksalar - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyTayfun Ates - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyMerve Oncul - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyIlknur Coban - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyEdanur Ates Oz - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyUtku Cebecioglu - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyMuhammed Ikbal Alp - Department of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, TurkeyBayram Yilmaz - Department of Physiology, School of Medicine, Yeditepe University, Istanbul, TurkeyDeniz Atasoy - Department of Pharmacology, Iowa Neuroscience Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA, deniz-atasoy@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Neuroendocrinology, Vol.110(3-4), pp.258-270
- Publisher
- Switzerland
- DOI
- 10.1159/000501234
- PMID
- 31154452
- ISSN
- 0028-3835
- eISSN
- 1423-0194
- Language
- English
- Date published
- 2020
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984065883402771
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