Journal article
MCU (Mitochondrial Ca 2+ Uniporter) makes the calcium go round
The Journal of biological chemistry, Vol.298(2), pp.101604-101604
01/17/2022
DOI: 10.1016/j.jbc.2022.101604
PMCID: PMC8819027
PMID: 35051417
Abstract
Store-operated Ca
entry (SOCE) is a major mechanism controlling Ca
signaling and Ca
-dependent functions and has been implicated in immunity, cancer, and organ development. SOCE-dependent cytosolic Ca
signals are affected by mitochondrial Ca
transport through several competing mechanisms. However, how these mechanisms interact in shaping Ca
dynamics and regulating Ca
-dependent functions remains unclear. In a recent issue, Yoast and colleagues shed light on these questions by defining multiple roles of the mitochondrial Ca
uniporter (MCU) in regulating SOCE, Ca
dynamics, transcription, and lymphocyte activation.
Details
- Title: Subtitle
- MCU (Mitochondrial Ca 2+ Uniporter) makes the calcium go round
- Creators
- Grant C Walters - Department of Neuroscience and Pharmacology, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242Yuriy M Usachev - Department of Neuroscience and Pharmacology, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242. Electronic address: yuriy-usachev@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- The Journal of biological chemistry, Vol.298(2), pp.101604-101604
- DOI
- 10.1016/j.jbc.2022.101604
- PMID
- 35051417
- PMCID
- PMC8819027
- NLM abbreviation
- J Biol Chem
- ISSN
- 0021-9258
- eISSN
- 1083-351X
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: DK116624, GM067795, NS096246, NS113189
- Language
- English
- Date published
- 01/17/2022
- Academic Unit
- Iowa Neuroscience Institute; Anesthesia; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology
- Record Identifier
- 9984211794502771
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