MDM2 copy numbers in well-differentiated and dedifferentiated liposarcoma: characterizing progression to high-grade tumors

Patrick L Ware; Anthony N Snow; Maya Gvalani; Mark J Pettenati; Shadi A Qasem

doi:10.1309/AJCPLYU89XHSNHQO

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MDM2 copy numbers in well-differentiated and dedifferentiated liposarcoma: characterizing progression to high-grade tumors

Journal article

Open access

Peer reviewed

MDM2 copy numbers in well-differentiated and dedifferentiated liposarcoma: characterizing progression to high-grade tumors

Patrick L Ware, Anthony N Snow, Maya Gvalani, Mark J Pettenati and Shadi A Qasem

American journal of clinical pathology, Vol.141(3), pp.334-341

03/2014

DOI: 10.1309/AJCPLYU89XHSNHQO

PMID: 24515760

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Abstract

MDM2 gene amplification is associated with well-differentiated (WDL) and dedifferentiated liposarcomas (DDL). Using fluorescent in situ hybridization (FISH), we sought to characterize various patterns of MDM2 amplification among the morphologic spectrum of liposarcoma. Forty-six cases of liposarcoma in various sites were examined and included 22 WDLs, 14 DLLs, and 10 negative control subjects. The MDM2 amplification ratio (MDM2/CEP12) was lower in WDL (10.2) compared with DDL (18.3) cases (P = .0000002). An amplification ratio of 16 showed optimal sensitivity (0.86) and specificity (0.96) as a cutoff point for progression to DDL. Borderline areas, defined as tumors with increased cellularity and atypia but with preserved lipomatous differentiation, showed a significantly higher MDM2 ratio (17.5; P = .0007) compared with WDL. Central (retroperitoneal and intra-abdominal) tumors also showed a significantly higher MDM2 ratio than peripheral ones (P = .02). Differences in MDM2 amplification profiles among liposarcomas could help further define and predict progression to high-grade neoplasia.

Proto-Oncogene Proteins c-mdm2 - genetics

Humans

Liposarcoma - pathology

Middle Aged

Liposarcoma - genetics

Male

Disease Progression

DNA Copy Number Variations

Cell Differentiation - genetics

Aged, 80 and over

Adult

Female

Aged

Biomarkers, Tumor - genetics

Details

Title: Subtitle: MDM2 copy numbers in well-differentiated and dedifferentiated liposarcoma: characterizing progression to high-grade tumors
Creators: Patrick L Ware - Dept of Pathology, Wake Forest Baptist Health, Medical Center Blvd, Winston-Salem, NC 27157; sqasem@wakehealth.edu
Anthony N Snow
Maya Gvalani
Mark J Pettenati
Shadi A Qasem
Resource Type: Journal article
Publication Details: American journal of clinical pathology, Vol.141(3), pp.334-341
DOI: 10.1309/AJCPLYU89XHSNHQO
PMID: 24515760
NLM abbreviation: Am J Clin Pathol
ISSN: 0002-9173
eISSN: 1943-7722
Publisher: England
Language: English
Date published: 03/2014
Academic Unit: Pathology
Record Identifier: 9984047766702771

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