Journal article
MECHANISMS OF TOTAL LYMPHOID IRRADIATION-INDUCED IMMUNOSUPPRESSION: II. FAILURE OF CON A-STIMULATED SPLENOCYTES FROM TLI-TREATED MICE TO EXPRESS IL-2 AND IL-2 RECEPTOR RNA
Transplantation, Vol.50(5), pp.839-844
11/1990
DOI: 10.1097/00007890-199011000-00019
PMID: 2238059
Abstract
Total lymphoid irradiation is a radiotherapy procedure used as an alternative immunosuppressive regimen in organ transplantation. Following TLI mature lymphocytes are depleted, and splenocytes do not proliferate to mitogens, produce IL-2, or express IL-2 receptors. We now show that mitogen stimulated splenocytes from TLI-treated mice do not secrete IL-2 protein by an IL-2 ELISA assay. Northern blot analysis and RNase protection assays reveal that TLI splenocytes do not make IL-2 RNA or IL-2 receptor RNA following mitogen stimulation. TLI splenocytes produce at least 1000 times less IL-2 RNA after Con A stimulation than normal splenocytes. TLI therapy resembles anti-CD4 therapy and CsA in that each results in an IL-2-"depleted" state.
Details
- Title: Subtitle
- MECHANISMS OF TOTAL LYMPHOID IRRADIATION-INDUCED IMMUNOSUPPRESSION: II. FAILURE OF CON A-STIMULATED SPLENOCYTES FROM TLI-TREATED MICE TO EXPRESS IL-2 AND IL-2 RECEPTOR RNA
- Creators
- ZHONG-XIANG YEGAIL C BECKERELIZABETH H FIELD
- Resource Type
- Journal article
- Publication Details
- Transplantation, Vol.50(5), pp.839-844
- DOI
- 10.1097/00007890-199011000-00019
- PMID
- 2238059
- ISSN
- 0041-1337
- eISSN
- 1534-6080
- Language
- English
- Date published
- 11/1990
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094760702771
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