Journal article
MEF2: a central regulator of diverse developmental programs
Development (Cambridge), Vol.134(23), pp.4131-4140
12/2007
DOI: 10.1242/dev.008367
PMID: 17959722
Abstract
The myocyte enhancer factor 2 (MEF2) transcription factor acts as a lynchpin in the transcriptional circuits that control cell differentiation and organogenesis. The spectrum of genes activated by MEF2 in different cell types depends on extracellular signaling and on co-factor interactions that modulate MEF2 activity. Recent studies have revealed MEF2 to form an intimate partnership with class IIa histone deacetylases, which together function as a point of convergence of multiple epigenetic regulatory mechanisms. We review the myriad roles of MEF2 in development and the mechanisms through which it couples developmental, physiological and pathological signals with programs of cell-specific transcription.
Details
- Title: Subtitle
- MEF2: a central regulator of diverse developmental programs
- Creators
- Matthew J Potthoff - Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USAEric N Olson
- Resource Type
- Journal article
- Publication Details
- Development (Cambridge), Vol.134(23), pp.4131-4140
- DOI
- 10.1242/dev.008367
- PMID
- 17959722
- NLM abbreviation
- Development
- ISSN
- 0950-1991
- eISSN
- 1477-9129
- Publisher
- England
- Language
- English
- Date published
- 12/2007
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984040593602771
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