METABOLICALLY HEALTHY OBESITY AND SUBCLINICAL ATHEROSCLEROSIS IN PERSONS WITH SPINAL CORD INJURY

Eun Sun Yoon; Kevin S. Heffernan; Sae Young Jae; Hyun Jeong Kim; Kanokwan Bunsawat; Bo Fernhall

doi:10.2340/16501977-2351

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METABOLICALLY HEALTHY OBESITY AND SUBCLINICAL ATHEROSCLEROSIS IN PERSONS WITH SPINAL CORD INJURY

Journal article

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Peer reviewed

METABOLICALLY HEALTHY OBESITY AND SUBCLINICAL ATHEROSCLEROSIS IN PERSONS WITH SPINAL CORD INJURY

Eun Sun Yoon, Kevin S. Heffernan, Sae Young Jae, Hyun Jeong Kim, Kanokwan Bunsawat and Bo Fernhall

Journal of rehabilitation medicine, Vol.50(7), pp.613-618

07/17/2018

DOI: 10.2340/16501977-2351

PMID: 29881872

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Abstract

Objective: Despite preserved metabolic function, metabolically healthy obesity may increase the risk of subclinical atherosclerosis. Given the high prevalence of cardiometabolic diseases in individuals with spinal cord injury, the aim of this study was to investigate the association of insulin resistance, systemic low-grade inflammation, and markers of subclinical atherosclerosis with metabolically healthy obesity in individuals with spinal cord injury. Methods: Insulin resistance index (HOMA-IR), high-sensitivity C-reactive protein, carotid artery intima-media thickness and carotid-femoral pulse wave velocity were measured in individuals with spinal cord injury classified with metabolically healthy obesity (n = 12), metabolically unhealthy obesity (n= 8), or metabolically healthy normal-weight (n = 18). Metabolically healthy obesity was defined as spinal cord injury-specific cut-off of body mass index >= 22 kg/m(2) with <3 metabolic abnormalities. Results: There were no differences in HOMA-IR or high-sensitivity C-reactive protein in metabolically healthy obesity compared with metabolically healthy normal-weight (p> 0.05). Pulse wave velocity was higher in metabolically healthy obesity than in metabolically healthy normal-weight (p <= 0.05), but lower than in metabolically unhealthy obesity (p <= 0.05). Metabolically healthy obesity had similar carotid artery intima-media thickness vs metabolically healthy normal-weight (p > 0.05), but lower carotid artery intima-media thickness compared with metabolically unhealthy obesity (p <= 5 0.05). Conclusion: Despite a somewhat preserved metabolic and inflammatory status, individuals with spinal cord injury with metabolically healthy obesity present with an intermediate subclinical atherosclerotic phenotype, as evidenced by increased aortic stiffness but not carotid thickness.

Life Sciences & Biomedicine

Rehabilitation

Science & Technology

Sport Sciences

Details

Title: Subtitle: METABOLICALLY HEALTHY OBESITY AND SUBCLINICAL ATHEROSCLEROSIS IN PERSONS WITH SPINAL CORD INJURY
Creators: Eun Sun Yoon - University of Seoul
Kevin S. Heffernan - Syracuse University
Sae Young Jae - University of Seoul
Hyun Jeong Kim - University of Seoul
Kanokwan Bunsawat - University of Illinois Chicago
Bo Fernhall - University of Illinois Urbana-Champaign
Resource Type: Journal article
Publication Details: Journal of rehabilitation medicine, Vol.50(7), pp.613-618
DOI: 10.2340/16501977-2351
PMID: 29881872
NLM abbreviation: J Rehabil Med
ISSN: 1650-1977
eISSN: 1651-2081
Publisher: Foundation Rehabilitation Information
Number of pages: 6
Grant note: Ministry of Education of the Republic of Korea; Ministry of Education (MOE), Republic of Korea NRF-2015S1A5A2A03049838 / National Research Foundation of Korea
Language: English
Date published: 07/17/2018
Academic Unit: Health, Sport, and Human Physiology
Record Identifier: 9984948043202771

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