Journal article
MG53's new identity
Skeletal muscle, Vol.3(1), pp.25-25
11/01/2013
DOI: 10.1186/2044-5040-3-25
PMID: 24175977
Abstract
Mitsugumin 53 (MG53) is a relatively newly identified tripartite motif-containing (TRIM) family muscle-specific E3 ubiquitin ligase that is expressed in skeletal muscle and the heart. It has been postulated to facilitate repair by targeting the site of an injury, and acting as a scaffold for assembly of a repair complex made up of dysferlin, annexin V, caveolin-3, and polymerase I and transcript release factor (PTRF). A recent letter published in Nature by Song et al. proposes an alternate function for MG53: as an E3 ligase that targets the insulin receptor and insulin receptor substrate 1 (IRS1) for degradation, therefore regulating muscle insulin signaling. This work is exciting, as it not only presents a novel role for MG53, but also suggests that muscle insulin signaling has a systemic influence on insulin resistance and the metabolic syndrome.
Details
- Title: Subtitle
- MG53's new identity
- Creators
- Jennifer R LevyKevin P CampbellDavid J Glass - Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA. david.glass@novartis.com
- Resource Type
- Journal article
- Publication Details
- Skeletal muscle, Vol.3(1), pp.25-25
- DOI
- 10.1186/2044-5040-3-25
- PMID
- 24175977
- NLM abbreviation
- Skelet Muscle
- ISSN
- 2044-5040
- eISSN
- 2044-5040
- Publisher
- England
- Language
- English
- Date published
- 11/01/2013
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984020876602771
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