MHC class Ia-restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2-M3)-restricted memory response

Sara E Hamilton; Brandon B Porter; Kelly A Nordyke Messingham; Vladimir P Badovinac; John T Harty

doi:10.1038/ni1026

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MHC class Ia-restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2-M3)-restricted memory response

Journal article

Peer reviewed

MHC class Ia-restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2-M3)-restricted memory response

Sara E Hamilton, Brandon B Porter, Kelly A Nordyke Messingham, Vladimir P Badovinac and John T Harty

Nature immunology, Vol.5(2), pp.159-168

02/2004

DOI: 10.1038/ni1026

PMID: 14745446

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Abstract

Listeria monocytogenes infection generates major histocompatibility complex (MHC) class Ia-restricted and MHC class Ib-(H2-M3)-restricted effector and memory CD8+ T cells. However, only MHC class Ia-restricted memory cells expand after rechallenge, and it is unknown if MHC class Ib-restricted memory CD8+ T cells generated by vaccination are protective. We show here that H2-M3-restricted memory CD8+ T cells were capable of secondary expansion but, in contrast to primary H2-M3-restricted effector cells, failed to provide protective immunity. In lm-immune mice, MHC class Ia-restricted memory CD8+ T cells prevented the expansion of H2-M3-restricted memory T cell populations by limiting dendritic cell antigen presentation. Thus, protective immunity by H2-M3-restricted T cells is limited to primary infection, indicating that memory MHC class Ia-restricted T cells prevent nonessential immune responses during secondary infection.

Dendritic Cells - immunology

Antigens, Bacterial - immunology

Mice, Transgenic

Listeria monocytogenes - immunology

Mice, Knockout

Histocompatibility Antigens Class I - metabolism

Animals

Antigen Presentation

Listeriosis - immunology

Female

Immunologic Memory

Mice

Mice, Inbred BALB C

CD8-Positive T-Lymphocytes - immunology

Cytotoxicity, Immunologic

Details

Title: Subtitle: MHC class Ia-restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2-M3)-restricted memory response
Creators: Sara E Hamilton - Interdisciplinary Program in Immunology, The University of Iowa, Iowa City, IA 52242, USA
Brandon B Porter
Kelly A Nordyke Messingham
Vladimir P Badovinac
John T Harty
Resource Type: Journal article
Publication Details: Nature immunology, Vol.5(2), pp.159-168
Publisher: United States
DOI: 10.1038/ni1026
PMID: 14745446
ISSN: 1529-2908
eISSN: 1529-2916
Grant note: T32 AI 07485 / NIAID NIH HHS AI 42767 / NIAID NIH HHS T32 AI 07511 / NIAID NIH HHS T32 GM007337 / NIGMS NIH HHS T32 AI 07260 / NIAID NIH HHS AI 46653 / NIAID NIH HHS AI 50073 / NIAID NIH HHS
Language: English
Date published: 02/2004
Academic Unit: Dermatology; Microbiology and Immunology; Pathology
Record Identifier: 9984025482502771

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